Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Yang Gao, Liyi Geng, Vicky Ping Chen, William Stephen Brimijoin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the peptide hormone ghrelin and its impact on hunger, obesity, and emotions. Here, we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention.

Original languageEnglish (US)
JournalMolecules (Basel, Switzerland)
Volume22
Issue number7
DOIs
StatePublished - Jul 8 2017

Fingerprint

Gene transfer
Butyrylcholinesterase
Ghrelin
Viral Genes
genes
brain
mice
Brain
delivery
obesity
emotions
Hunger
hormones
Peptide Hormones
activity (biology)
liver
food
Liver
peptides
enzymes

Keywords

  • AAV-9
  • AAV-PHP.B
  • adeno-associated virus (AAV)-8
  • butyrylcholinesterase
  • enzyme expression
  • ghrelin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice. / Gao, Yang; Geng, Liyi; Chen, Vicky Ping; Brimijoin, William Stephen.

In: Molecules (Basel, Switzerland), Vol. 22, No. 7, 08.07.2017.

Research output: Contribution to journalArticle

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