Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Yang Gao; Liyi Geng; Vicky Ping Chen; Stephen Brimijoin

doi:10.3390/molecules22071145

Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Yang Gao, Liyi Geng, Vicky Ping Chen, Stephen Brimijoin

Pharmacology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the peptide hormone ghrelin and its impact on hunger, obesity, and emotions. Here, we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention.

Original language	English (US)
Journal	Molecules (Basel, Switzerland)
Volume	22
Issue number	7
DOIs	https://doi.org/10.3390/molecules22071145
State	Published - Jul 8 2017

Keywords

AAV-9
AAV-PHP.B
adeno-associated virus (AAV)-8
butyrylcholinesterase
enzyme expression
ghrelin

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules22071145

Cite this

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abstract = "Recent research shows that butyrylcholinesterase (BChE) is not simply a liver enzyme that detoxifies bioactive esters in food and medications. In fact, in pursuing other goals, we recently found that it has an equally important role in regulating the peptide hormone ghrelin and its impact on hunger, obesity, and emotions. Here, we present and examine means of manipulating brain BChE levels by viral gene transfer, either regionally or globally, to modulate ghrelin signaling for long-term therapeutic purposes and to set the stage for exploring the neurophysiological impact of such an intervention.",

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AU - Brimijoin, Stephen

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Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice

Abstract

Keywords

ASJC Scopus subject areas

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