Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics

Joseph F. Poduslo, Shelly L. Whelan, Geoffry L. Curran, Thomas M. Wengenack

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Continuous subcutaneous administration of polyamine-modified catalase that has increased permeability at the blood-brain barrier showed both a highly significant delay in onset and an increase in survival in a transgenic mouse model of familial amyotrophic lateral sclerosis having a point mutation in the gene encoding copper/zinc superoxide dismutase. These results suggest that hydrogen peroxide-mediated oxidative stress with subsequent free radical damage involving nitric oxide and possibly hydroxyl radicals in motor neurons may be the culprit in familial amyotrophic lateral sclerosis.

Original languageEnglish (US)
Pages (from-to)943-947
Number of pages5
JournalAnnals of Neurology
Volume48
Issue number6
DOIs
StatePublished - 2000

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Polyamines
Catalase
Hydrogen Peroxide
Nitric Oxide
Water
Motor Neurons
Blood-Brain Barrier
Point Mutation
Hydroxyl Radical
Transgenic Mice
Superoxide Dismutase
Free Radicals
Zinc
Copper
Permeability
Oxidative Stress
Therapeutics
Genes
Amyotrophic lateral sclerosis 1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics. / Poduslo, Joseph F.; Whelan, Shelly L.; Curran, Geoffry L.; Wengenack, Thomas M.

In: Annals of Neurology, Vol. 48, No. 6, 2000, p. 943-947.

Research output: Contribution to journalArticle

Poduslo, Joseph F. ; Whelan, Shelly L. ; Curran, Geoffry L. ; Wengenack, Thomas M. / Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics. In: Annals of Neurology. 2000 ; Vol. 48, No. 6. pp. 943-947.
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