Therapeutic advances in alcohol-associated hepatitis

Gyongyi Szabo, Mark Thursz, Vijay H. Shah

Research output: Contribution to journalReview articlepeer-review


In recent years, there have been important advances in our understanding of alcohol-associated hepatitis (AH), which have occurred in parallel with a surge in clinical trial activity. Meanwhile, the broader medical field has seen a transformation in care paradigms based on emerging digital technologies. This review focuses on breakthroughs in our understanding of AH and how these breakthroughs are leading to new paradigms for biomarker discovery, clinical trial activity, and care models for patients. It portends a future in which multimodal data from genetic, radiomic, histologic, and environmental sources can be integrated and synthesised to generate personalised biomarkers and therapies for patients with AH.

Original languageEnglish (US)
Pages (from-to)1279-1290
Number of pages12
JournalJournal of hepatology
Issue number6
StatePublished - Jun 2022


  • Microbiome
  • Systemic inflammatory response syndrome
  • Trial design

ASJC Scopus subject areas

  • Hepatology


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