TY - JOUR
T1 - Therapeutic advances in alcohol-associated hepatitis
AU - Szabo, Gyongyi
AU - Thursz, Mark
AU - Shah, Vijay H.
N1 - Funding Information:
MT receives grant funding from the UK Medical Research Council and acknowledges support from NIHR Imperial Biomedical Research Centre .
Funding Information:
GS receives funding from the National Institute on Alcoholism and Alcohol Abuse and National Institute on Aging.
Publisher Copyright:
© 2022 European Association for the Study of the Liver
PY - 2022/6
Y1 - 2022/6
N2 - In recent years, there have been important advances in our understanding of alcohol-associated hepatitis (AH), which have occurred in parallel with a surge in clinical trial activity. Meanwhile, the broader medical field has seen a transformation in care paradigms based on emerging digital technologies. This review focuses on breakthroughs in our understanding of AH and how these breakthroughs are leading to new paradigms for biomarker discovery, clinical trial activity, and care models for patients. It portends a future in which multimodal data from genetic, radiomic, histologic, and environmental sources can be integrated and synthesised to generate personalised biomarkers and therapies for patients with AH.
AB - In recent years, there have been important advances in our understanding of alcohol-associated hepatitis (AH), which have occurred in parallel with a surge in clinical trial activity. Meanwhile, the broader medical field has seen a transformation in care paradigms based on emerging digital technologies. This review focuses on breakthroughs in our understanding of AH and how these breakthroughs are leading to new paradigms for biomarker discovery, clinical trial activity, and care models for patients. It portends a future in which multimodal data from genetic, radiomic, histologic, and environmental sources can be integrated and synthesised to generate personalised biomarkers and therapies for patients with AH.
KW - Microbiome
KW - Systemic inflammatory response syndrome
KW - Trial design
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U2 - 10.1016/j.jhep.2022.03.025
DO - 10.1016/j.jhep.2022.03.025
M3 - Review article
C2 - 35589250
AN - SCOPUS:85129920138
SN - 0168-8278
VL - 76
SP - 1279
EP - 1290
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 6
ER -