Theoretical limits of spatial resolution in elliptical-centric contrast- enhanced 3D-MRA

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Abstract

The point spread function (PSF) for contrast-enhanced three-dimensional (3D) MR angiography using the elliptical centric view order is derived. This view order has been shown previously to provide high venous suppression thereby enabling long acquisition times capable of high spatial resolution. The dependence of the PSF on TR, field of view (FOV), scan time, and trigger time are shown explicitly. Theoretical predictions are corroborated with experimental results in phantoms and in vivo. The PSF width decreases as the square root of the product of TR and the two phase encoding FOV's for fixed nominal voxel size. The PSF peak amplitude increases as the reciprocal of this product. Theory and experiment demonstrate that acquisition times over 40 sec provide superior resolution compared to shorter acquisitions, despite falling levels of contrast agent concentration. The analysis predicts that an isotropic spatial resolution of 1 mm before zero filling is possible in a FOV large enough to encompass the carotid and vertebral arteries bilaterally.

Original languageEnglish (US)
Pages (from-to)1106-1116
Number of pages11
JournalMagnetic Resonance in Medicine
Volume42
Issue number6
DOIs
StatePublished - 1999

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Vertebral Artery
Carotid Arteries
Contrast Media
Angiography

Keywords

  • Contrast-enhanced MRA
  • Elliptical centric view order
  • MR angiography
  • Point spread function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

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title = "Theoretical limits of spatial resolution in elliptical-centric contrast- enhanced 3D-MRA",
abstract = "The point spread function (PSF) for contrast-enhanced three-dimensional (3D) MR angiography using the elliptical centric view order is derived. This view order has been shown previously to provide high venous suppression thereby enabling long acquisition times capable of high spatial resolution. The dependence of the PSF on TR, field of view (FOV), scan time, and trigger time are shown explicitly. Theoretical predictions are corroborated with experimental results in phantoms and in vivo. The PSF width decreases as the square root of the product of TR and the two phase encoding FOV's for fixed nominal voxel size. The PSF peak amplitude increases as the reciprocal of this product. Theory and experiment demonstrate that acquisition times over 40 sec provide superior resolution compared to shorter acquisitions, despite falling levels of contrast agent concentration. The analysis predicts that an isotropic spatial resolution of 1 mm before zero filling is possible in a FOV large enough to encompass the carotid and vertebral arteries bilaterally.",
keywords = "Contrast-enhanced MRA, Elliptical centric view order, MR angiography, Point spread function",
author = "Fain, {Sean B.} and Riederer, {Stephen J} and Bernstein, {Matthew A} and Huston, {John III}",
year = "1999",
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T1 - Theoretical limits of spatial resolution in elliptical-centric contrast- enhanced 3D-MRA

AU - Fain, Sean B.

AU - Riederer, Stephen J

AU - Bernstein, Matthew A

AU - Huston, John III

PY - 1999

Y1 - 1999

N2 - The point spread function (PSF) for contrast-enhanced three-dimensional (3D) MR angiography using the elliptical centric view order is derived. This view order has been shown previously to provide high venous suppression thereby enabling long acquisition times capable of high spatial resolution. The dependence of the PSF on TR, field of view (FOV), scan time, and trigger time are shown explicitly. Theoretical predictions are corroborated with experimental results in phantoms and in vivo. The PSF width decreases as the square root of the product of TR and the two phase encoding FOV's for fixed nominal voxel size. The PSF peak amplitude increases as the reciprocal of this product. Theory and experiment demonstrate that acquisition times over 40 sec provide superior resolution compared to shorter acquisitions, despite falling levels of contrast agent concentration. The analysis predicts that an isotropic spatial resolution of 1 mm before zero filling is possible in a FOV large enough to encompass the carotid and vertebral arteries bilaterally.

AB - The point spread function (PSF) for contrast-enhanced three-dimensional (3D) MR angiography using the elliptical centric view order is derived. This view order has been shown previously to provide high venous suppression thereby enabling long acquisition times capable of high spatial resolution. The dependence of the PSF on TR, field of view (FOV), scan time, and trigger time are shown explicitly. Theoretical predictions are corroborated with experimental results in phantoms and in vivo. The PSF width decreases as the square root of the product of TR and the two phase encoding FOV's for fixed nominal voxel size. The PSF peak amplitude increases as the reciprocal of this product. Theory and experiment demonstrate that acquisition times over 40 sec provide superior resolution compared to shorter acquisitions, despite falling levels of contrast agent concentration. The analysis predicts that an isotropic spatial resolution of 1 mm before zero filling is possible in a FOV large enough to encompass the carotid and vertebral arteries bilaterally.

KW - Contrast-enhanced MRA

KW - Elliptical centric view order

KW - MR angiography

KW - Point spread function

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