The yin and yang of autophagy in AL amyloidosis

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

In this issue of Blood, Oliva et al report on a series of experiments that have demonstrated that in systemic light chain (AL) plasma cells (PCs), there is a complex interaction between those PCs and the immunoglobulin light chains (LCs) they produce.1 The pathology introduced by these unstable amyloidogenic LCs occurs not only at distant organs2,3 but also in the plasma cells that produce them. This manuscript attempts to unravel the relationship of AL LCs and the PCs that produce them in the context of AL PC susceptibility to proteasome inhibitors and the role autophagy may play in that susceptibility.

Original languageEnglish (US)
Pages (from-to)2044-2045
Number of pages2
JournalBlood
Volume129
Issue number15
DOIs
StatePublished - Apr 13 2017

Fingerprint

Yin-Yang
Autophagy
Amyloidosis
Plasma Cells
Plasmas
Light
Immunoglobulin Light Chains
Proteasome Inhibitors
Beam plasma interactions
Pathology
Blood
Experiments

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

The yin and yang of autophagy in AL amyloidosis. / Dispenzieri, Angela.

In: Blood, Vol. 129, No. 15, 13.04.2017, p. 2044-2045.

Research output: Contribution to journalComment/debate

Dispenzieri, Angela. / The yin and yang of autophagy in AL amyloidosis. In: Blood. 2017 ; Vol. 129, No. 15. pp. 2044-2045.
@article{5c35528b4f0b4bf28c86ec1b88078a8c,
title = "The yin and yang of autophagy in AL amyloidosis",
abstract = "In this issue of Blood, Oliva et al report on a series of experiments that have demonstrated that in systemic light chain (AL) plasma cells (PCs), there is a complex interaction between those PCs and the immunoglobulin light chains (LCs) they produce.1 The pathology introduced by these unstable amyloidogenic LCs occurs not only at distant organs2,3 but also in the plasma cells that produce them. This manuscript attempts to unravel the relationship of AL LCs and the PCs that produce them in the context of AL PC susceptibility to proteasome inhibitors and the role autophagy may play in that susceptibility.",
author = "Angela Dispenzieri",
year = "2017",
month = "4",
day = "13",
doi = "10.1182/blood-2017-02-765594",
language = "English (US)",
volume = "129",
pages = "2044--2045",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "15",

}

TY - JOUR

T1 - The yin and yang of autophagy in AL amyloidosis

AU - Dispenzieri, Angela

PY - 2017/4/13

Y1 - 2017/4/13

N2 - In this issue of Blood, Oliva et al report on a series of experiments that have demonstrated that in systemic light chain (AL) plasma cells (PCs), there is a complex interaction between those PCs and the immunoglobulin light chains (LCs) they produce.1 The pathology introduced by these unstable amyloidogenic LCs occurs not only at distant organs2,3 but also in the plasma cells that produce them. This manuscript attempts to unravel the relationship of AL LCs and the PCs that produce them in the context of AL PC susceptibility to proteasome inhibitors and the role autophagy may play in that susceptibility.

AB - In this issue of Blood, Oliva et al report on a series of experiments that have demonstrated that in systemic light chain (AL) plasma cells (PCs), there is a complex interaction between those PCs and the immunoglobulin light chains (LCs) they produce.1 The pathology introduced by these unstable amyloidogenic LCs occurs not only at distant organs2,3 but also in the plasma cells that produce them. This manuscript attempts to unravel the relationship of AL LCs and the PCs that produce them in the context of AL PC susceptibility to proteasome inhibitors and the role autophagy may play in that susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=85028301195&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028301195&partnerID=8YFLogxK

U2 - 10.1182/blood-2017-02-765594

DO - 10.1182/blood-2017-02-765594

M3 - Comment/debate

VL - 129

SP - 2044

EP - 2045

JO - Blood

JF - Blood

SN - 0006-4971

IS - 15

ER -