Abstract
The cytotoxic T-lymphocyte-mediated killing of virus-infected cells requires previous recognition of short viral antigenic peptides bound to human leukocyte antigen class I molecules that are exposed on the surface of infected cells. The cytotoxic T-lymphocyte response is critical for the clearance of human respiratory syncytial virus infection. In this study, naturally processed viral human leukocyte antigen class I ligands were identified with mass spectrometry analysis of complex human leukocyte antigen-bound peptide pools isolated from large amounts of human respiratory syncytial virus-infected cells. Acute antiviral T-cell response characterization showed that viral transcription determines both the immunoprevalence and immunodominance of the human leukocyte antigen class I response to human respiratory syncytial virus. These findings have clear implications for antiviral vaccine design.
Original language | English (US) |
---|---|
Pages (from-to) | 893-904 |
Number of pages | 12 |
Journal | Molecular and Cellular Proteomics |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2015 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Molecular Biology