The viral transcription group determines the HLA class I cellular immune response against human respiratory syncytial virus

Carolina Johnstone, Elena Lorente, Alejandro Barriga, Eilon Barnea, Susana Infantes, François A. Lemonnier, Chella S. David, Arie Admon, Daniel López

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The cytotoxic T-lymphocyte-mediated killing of virus-infected cells requires previous recognition of short viral antigenic peptides bound to human leukocyte antigen class I molecules that are exposed on the surface of infected cells. The cytotoxic T-lymphocyte response is critical for the clearance of human respiratory syncytial virus infection. In this study, naturally processed viral human leukocyte antigen class I ligands were identified with mass spectrometry analysis of complex human leukocyte antigen-bound peptide pools isolated from large amounts of human respiratory syncytial virus-infected cells. Acute antiviral T-cell response characterization showed that viral transcription determines both the immunoprevalence and immunodominance of the human leukocyte antigen class I response to human respiratory syncytial virus. These findings have clear implications for antiviral vaccine design.

Original languageEnglish (US)
Pages (from-to)893-904
Number of pages12
JournalMolecular and Cellular Proteomics
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'The viral transcription group determines the HLA class I cellular immune response against human respiratory syncytial virus'. Together they form a unique fingerprint.

Cite this