The value of resting-state functional MRI in subacute ischemic stroke: Comparison with dynamic susceptibility contrast-enhanced perfusion MRI

Ling Ni, Jingwei Li, Weiping Li, Fei Zhou, Fangfang Wang, Christopher Schwarz, Renyuan Liu, Hui Zhao, Wenbo Wu, Xin Zhang, Ming Li, Haiping Yu, Bin Zhu, Arno Villringer, Yufeng Zang, Bing Zhang, Yating Lv, Yun Xu

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Abstract

To evaluate the potential clinical value of the time-shift analysis (TSA) approach for resting-state fMRI (rs-fMRI) blood oxygenation level-dependent (BOLD) data in detecting hypoperfusion of subacute stroke patients through comparison with dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI). Forty patients with subacute stroke (3-14 days after neurological symptom onset) underwent MRI examination. Cohort A: 31 patients had MRA, DSC-PWI and BOLD data. Cohort B: 9 patients had BOLD and MRA data. The time delay between the BOLD time course in each voxel and the mean signal of global and contralateral hemisphere was calculated using TSA. Time to peak (TTP) was employed to detect hypoperfusion. Among cohort A, 14 patients who had intracranial large-vessel occlusion/stenosis with sparse collaterals showed hypoperfusion by both of the two approaches, one with abundant collaterals showed neither TTP nor TSA time delay. The remaining 16 patients without obvious MRA lesions showed neither TTP nor TSA time delay. Among cohort B, eight patients showed time delay areas. The TSA approach was a promising alternative to DSC-PWI for detecting hypoperfusion in subacute stroke patients who had obvious MRA lesions with sparse collaterals, those with abundant collaterals would keep intact local perfusion.

Original languageEnglish (US)
Article number41586
JournalScientific reports
Volume7
DOIs
StatePublished - Jan 31 2017

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Perfusion
Stroke
Magnetic Resonance Imaging
Perfusion Imaging
Pathologic Constriction

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The value of resting-state functional MRI in subacute ischemic stroke : Comparison with dynamic susceptibility contrast-enhanced perfusion MRI. / Ni, Ling; Li, Jingwei; Li, Weiping; Zhou, Fei; Wang, Fangfang; Schwarz, Christopher; Liu, Renyuan; Zhao, Hui; Wu, Wenbo; Zhang, Xin; Li, Ming; Yu, Haiping; Zhu, Bin; Villringer, Arno; Zang, Yufeng; Zhang, Bing; Lv, Yating; Xu, Yun.

In: Scientific reports, Vol. 7, 41586, 31.01.2017.

Research output: Contribution to journalArticle

Ni, L, Li, J, Li, W, Zhou, F, Wang, F, Schwarz, C, Liu, R, Zhao, H, Wu, W, Zhang, X, Li, M, Yu, H, Zhu, B, Villringer, A, Zang, Y, Zhang, B, Lv, Y & Xu, Y 2017, 'The value of resting-state functional MRI in subacute ischemic stroke: Comparison with dynamic susceptibility contrast-enhanced perfusion MRI', Scientific reports, vol. 7, 41586. https://doi.org/10.1038/srep41586
Ni, Ling ; Li, Jingwei ; Li, Weiping ; Zhou, Fei ; Wang, Fangfang ; Schwarz, Christopher ; Liu, Renyuan ; Zhao, Hui ; Wu, Wenbo ; Zhang, Xin ; Li, Ming ; Yu, Haiping ; Zhu, Bin ; Villringer, Arno ; Zang, Yufeng ; Zhang, Bing ; Lv, Yating ; Xu, Yun. / The value of resting-state functional MRI in subacute ischemic stroke : Comparison with dynamic susceptibility contrast-enhanced perfusion MRI. In: Scientific reports. 2017 ; Vol. 7.
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abstract = "To evaluate the potential clinical value of the time-shift analysis (TSA) approach for resting-state fMRI (rs-fMRI) blood oxygenation level-dependent (BOLD) data in detecting hypoperfusion of subacute stroke patients through comparison with dynamic susceptibility contrast perfusion weighted imaging (DSC-PWI). Forty patients with subacute stroke (3-14 days after neurological symptom onset) underwent MRI examination. Cohort A: 31 patients had MRA, DSC-PWI and BOLD data. Cohort B: 9 patients had BOLD and MRA data. The time delay between the BOLD time course in each voxel and the mean signal of global and contralateral hemisphere was calculated using TSA. Time to peak (TTP) was employed to detect hypoperfusion. Among cohort A, 14 patients who had intracranial large-vessel occlusion/stenosis with sparse collaterals showed hypoperfusion by both of the two approaches, one with abundant collaterals showed neither TTP nor TSA time delay. The remaining 16 patients without obvious MRA lesions showed neither TTP nor TSA time delay. Among cohort B, eight patients showed time delay areas. The TSA approach was a promising alternative to DSC-PWI for detecting hypoperfusion in subacute stroke patients who had obvious MRA lesions with sparse collaterals, those with abundant collaterals would keep intact local perfusion.",
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AU - Yu, Haiping

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