The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome

Anita D'Souza, Suzanne R. Hayman, Francis Buadi, Michelle Mauermann, Martha Q. Lacy, Morie A. Gertz, Robert A. Kyle, Shaji Kumar, Philip R. Greipp, John A. Lust, Stephen J. Russell, Steven Zeldenrust, David Dingli, Thomas E. Witzig, S. Vincent Rajkumar, Angela Dispenzieri

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

The POEMS syndrome is associated with elevated vascular endothelial growth factor (VEGF) levels. Several studies have compared serum VEGF levels between POEMS patients and other disease entities showing higher serum VEGF in POEMS syndrome; however, it is unknown whether serum levels are reliable and reproducible given variable platelet release of VEGF. We therefore compared plasma levels of VEGF in 29 patients with POEMS syndrome with those of other disorders (n = 76). We demonstrated that plasma VEGF levels are useful in differentiating POEMS from other plasma cell dyscrasias, neuropathic processes, and multisystem illnesses. Plasma VEGF is also useful in monitoring disease activity after treatment and correlates with clinical improvements better than hematologic response.

Original languageEnglish (US)
Pages (from-to)4663-4665
Number of pages3
JournalBlood
Volume118
Issue number17
DOIs
StatePublished - Oct 27 2011

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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