The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer: A single-center experience

Mohamad A. Eloubeidi, Michael B. Wallace, Carolyn E. Reed, Neven Hadzijahic, David N. Lewin, Annette Van Velse, Margaret B. Leveen, Babak Etemad, Koji Matsuda, Rig S. Patel, Robert H. Hawes, Brenda J. Hoffman

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Abstract

Background: The aims of this study were to determine the utility of EUS and EUS-guided fine needle aspiration (EUS-FNA) in the detection and confirmation of celiac lymph node metastasis in patients with esophageal cancer and to define EUS features predictive of celiac lymph node metastasis in these patients. Methods: The records of 211 patients with esophageal cancer who underwent EUS staging were reviewed. The operating characteristics of EUS were determined in patients where either surgery, EUS-FNA of a celiac lymph node, or both were performed (n = 102). The association between selected variables and the presence of celiac lymph node metastasis was evaluated by univariate and multivariable analyses. Results: EUS in 48 patients provided a true-positive diagnosis of celiac lymph node involvement, a false-positive and false-negative result, respectively, in 6 and 14 patients, and a true-negative diagnosis in 34 patients. The sensitivity of EUS in detecting celiac lymph node was 77% (95% Cl [67, 88]), specificity 85% (95% Cl [74, 96]), negative predictive value 71% (95% Cl [58, 84]), and the positive predictive value 89% (95% Cl [81, 97]). EUS-FNA was performed in 94% (51/54) of patients with celiac lymph nodes. The accuracy of EUS-FNA in detecting malignant celiac lymph nodes was 98% (95% Cl [90, 100]). Advanced T-stage, the need for dilation, detection of peritumoral lymph nodes, and black race were associated with celiac lymph node involvement. In multivariable analysis, advanced T-stage was the strongest predictor of celiac lymph node involvement. Conclusion: EUS and EUS-FNA are highly accurate in detecting and confirming celiac lymph nodes metastasis. Depth of tumor invasion as assessed by EUS is a strong predictor of celiac lymph node metastasis in patients with esophageal cancer.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalGastrointestinal Endoscopy
Volume54
Issue number6
DOIs
StatePublished - Dec 2001
Externally publishedYes

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Esophageal Neoplasms
Fine Needle Biopsy
Abdomen
Lymph Nodes
Neoplasm Metastasis
Dilatation

ASJC Scopus subject areas

  • Gastroenterology

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The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer : A single-center experience. / Eloubeidi, Mohamad A.; Wallace, Michael B.; Reed, Carolyn E.; Hadzijahic, Neven; Lewin, David N.; Van Velse, Annette; Leveen, Margaret B.; Etemad, Babak; Matsuda, Koji; Patel, Rig S.; Hawes, Robert H.; Hoffman, Brenda J.

In: Gastrointestinal Endoscopy, Vol. 54, No. 6, 12.2001, p. 714-719.

Research output: Contribution to journalArticle

Eloubeidi, MA, Wallace, MB, Reed, CE, Hadzijahic, N, Lewin, DN, Van Velse, A, Leveen, MB, Etemad, B, Matsuda, K, Patel, RS, Hawes, RH & Hoffman, BJ 2001, 'The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer: A single-center experience', Gastrointestinal Endoscopy, vol. 54, no. 6, pp. 714-719. https://doi.org/10.1067/mge.2001.119873
Eloubeidi, Mohamad A. ; Wallace, Michael B. ; Reed, Carolyn E. ; Hadzijahic, Neven ; Lewin, David N. ; Van Velse, Annette ; Leveen, Margaret B. ; Etemad, Babak ; Matsuda, Koji ; Patel, Rig S. ; Hawes, Robert H. ; Hoffman, Brenda J. / The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer : A single-center experience. In: Gastrointestinal Endoscopy. 2001 ; Vol. 54, No. 6. pp. 714-719.
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abstract = "Background: The aims of this study were to determine the utility of EUS and EUS-guided fine needle aspiration (EUS-FNA) in the detection and confirmation of celiac lymph node metastasis in patients with esophageal cancer and to define EUS features predictive of celiac lymph node metastasis in these patients. Methods: The records of 211 patients with esophageal cancer who underwent EUS staging were reviewed. The operating characteristics of EUS were determined in patients where either surgery, EUS-FNA of a celiac lymph node, or both were performed (n = 102). The association between selected variables and the presence of celiac lymph node metastasis was evaluated by univariate and multivariable analyses. Results: EUS in 48 patients provided a true-positive diagnosis of celiac lymph node involvement, a false-positive and false-negative result, respectively, in 6 and 14 patients, and a true-negative diagnosis in 34 patients. The sensitivity of EUS in detecting celiac lymph node was 77{\%} (95{\%} Cl [67, 88]), specificity 85{\%} (95{\%} Cl [74, 96]), negative predictive value 71{\%} (95{\%} Cl [58, 84]), and the positive predictive value 89{\%} (95{\%} Cl [81, 97]). EUS-FNA was performed in 94{\%} (51/54) of patients with celiac lymph nodes. The accuracy of EUS-FNA in detecting malignant celiac lymph nodes was 98{\%} (95{\%} Cl [90, 100]). Advanced T-stage, the need for dilation, detection of peritumoral lymph nodes, and black race were associated with celiac lymph node involvement. In multivariable analysis, advanced T-stage was the strongest predictor of celiac lymph node involvement. Conclusion: EUS and EUS-FNA are highly accurate in detecting and confirming celiac lymph nodes metastasis. Depth of tumor invasion as assessed by EUS is a strong predictor of celiac lymph node metastasis in patients with esophageal cancer.",
author = "Eloubeidi, {Mohamad A.} and Wallace, {Michael B.} and Reed, {Carolyn E.} and Neven Hadzijahic and Lewin, {David N.} and {Van Velse}, Annette and Leveen, {Margaret B.} and Babak Etemad and Koji Matsuda and Patel, {Rig S.} and Hawes, {Robert H.} and Hoffman, {Brenda J.}",
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T1 - The utility of EUS and EUS-guided fine needle aspiration in detecting celiac lymph node metastasis in patients with esophageal cancer

T2 - A single-center experience

AU - Eloubeidi, Mohamad A.

AU - Wallace, Michael B.

AU - Reed, Carolyn E.

AU - Hadzijahic, Neven

AU - Lewin, David N.

AU - Van Velse, Annette

AU - Leveen, Margaret B.

AU - Etemad, Babak

AU - Matsuda, Koji

AU - Patel, Rig S.

AU - Hawes, Robert H.

AU - Hoffman, Brenda J.

PY - 2001/12

Y1 - 2001/12

N2 - Background: The aims of this study were to determine the utility of EUS and EUS-guided fine needle aspiration (EUS-FNA) in the detection and confirmation of celiac lymph node metastasis in patients with esophageal cancer and to define EUS features predictive of celiac lymph node metastasis in these patients. Methods: The records of 211 patients with esophageal cancer who underwent EUS staging were reviewed. The operating characteristics of EUS were determined in patients where either surgery, EUS-FNA of a celiac lymph node, or both were performed (n = 102). The association between selected variables and the presence of celiac lymph node metastasis was evaluated by univariate and multivariable analyses. Results: EUS in 48 patients provided a true-positive diagnosis of celiac lymph node involvement, a false-positive and false-negative result, respectively, in 6 and 14 patients, and a true-negative diagnosis in 34 patients. The sensitivity of EUS in detecting celiac lymph node was 77% (95% Cl [67, 88]), specificity 85% (95% Cl [74, 96]), negative predictive value 71% (95% Cl [58, 84]), and the positive predictive value 89% (95% Cl [81, 97]). EUS-FNA was performed in 94% (51/54) of patients with celiac lymph nodes. The accuracy of EUS-FNA in detecting malignant celiac lymph nodes was 98% (95% Cl [90, 100]). Advanced T-stage, the need for dilation, detection of peritumoral lymph nodes, and black race were associated with celiac lymph node involvement. In multivariable analysis, advanced T-stage was the strongest predictor of celiac lymph node involvement. Conclusion: EUS and EUS-FNA are highly accurate in detecting and confirming celiac lymph nodes metastasis. Depth of tumor invasion as assessed by EUS is a strong predictor of celiac lymph node metastasis in patients with esophageal cancer.

AB - Background: The aims of this study were to determine the utility of EUS and EUS-guided fine needle aspiration (EUS-FNA) in the detection and confirmation of celiac lymph node metastasis in patients with esophageal cancer and to define EUS features predictive of celiac lymph node metastasis in these patients. Methods: The records of 211 patients with esophageal cancer who underwent EUS staging were reviewed. The operating characteristics of EUS were determined in patients where either surgery, EUS-FNA of a celiac lymph node, or both were performed (n = 102). The association between selected variables and the presence of celiac lymph node metastasis was evaluated by univariate and multivariable analyses. Results: EUS in 48 patients provided a true-positive diagnosis of celiac lymph node involvement, a false-positive and false-negative result, respectively, in 6 and 14 patients, and a true-negative diagnosis in 34 patients. The sensitivity of EUS in detecting celiac lymph node was 77% (95% Cl [67, 88]), specificity 85% (95% Cl [74, 96]), negative predictive value 71% (95% Cl [58, 84]), and the positive predictive value 89% (95% Cl [81, 97]). EUS-FNA was performed in 94% (51/54) of patients with celiac lymph nodes. The accuracy of EUS-FNA in detecting malignant celiac lymph nodes was 98% (95% Cl [90, 100]). Advanced T-stage, the need for dilation, detection of peritumoral lymph nodes, and black race were associated with celiac lymph node involvement. In multivariable analysis, advanced T-stage was the strongest predictor of celiac lymph node involvement. Conclusion: EUS and EUS-FNA are highly accurate in detecting and confirming celiac lymph nodes metastasis. Depth of tumor invasion as assessed by EUS is a strong predictor of celiac lymph node metastasis in patients with esophageal cancer.

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