The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation following pars plana vitrectomy with long-acting gas tamponade

R. A. Mittra, J. S. Pollack, S. Dev, D. P. Han, W. F. Mieler, J. S. Pulido, T. B. Connor, G. W. Weinstein, P. R. Lichter, P. Tornambe, M. Elman

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Purpose: To determine if topical aqueous suppressant therapy applied after pars plana vitrectomy (PPV) with gas tamponade successfully prevents postoperative elevation of intraocular pressure (IOP). Methods: A prospective, controlled study was performed on patients who met inclusion criteria and underwent PPV with gas tamponade (SF6 18%-20% or C3F8 12%- 16%) over a 1-year period. Treatment eyes received topical aqueous suppressants at the end of surgery. Postoperative IOP checks were performed at 4 to 6 hours, 1 day, and 1 week. Results: Twenty-one control (C) and 20 treatment (T) eyes met the inclusion criteria. The IOP (in mm Hg) measured at 4 to 6 hours (23.05 [C], 14.73 [T]) and 1 day (23.24 [C], 17.28 [T]) postoperatively showed a statistically significant difference between the groups (P =.0038) at 4 to 6 hours, and a trend toward significance (P =.057) at 1 day. Eleven control and 3 treatment eyes had an IOP spike above 25 mm Hg at 4 to 6 hours or 1 day postoperatively (P =.02), and 6 control and 1 treatment eye had a postoperative IOP above 30 mm Hg. A pressure rise above 40 mm Hg was seen in 2 control eyes and no treatment eyes. Conclusions: Use of topical aqueous suppressants following PPV with long-acting gas tamponade is effective in preventing significant postoperative IOP elevation in a majority of cases.

Original languageEnglish (US)
Pages (from-to)143-154
Number of pages12
JournalTransactions of the American Ophthalmological Society
Volume96
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation following pars plana vitrectomy with long-acting gas tamponade'. Together they form a unique fingerprint.

  • Cite this

    Mittra, R. A., Pollack, J. S., Dev, S., Han, D. P., Mieler, W. F., Pulido, J. S., Connor, T. B., Weinstein, G. W., Lichter, P. R., Tornambe, P., & Elman, M. (1998). The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation following pars plana vitrectomy with long-acting gas tamponade. Transactions of the American Ophthalmological Society, 96, 143-154.