The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation following pars plana vitrectomy with long-acting gas tamponade

R. A. Mittra, J. S. Pollack, S. Dev, D. P. Han, W. F. Mieler, Jose S Pulido, T. B. Connor, G. W. Weinstein, P. R. Lichter, P. Tornambe, M. Elman

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Abstract

Purpose: To determine if topical aqueous suppressant therapy applied after pars plana vitrectomy (PPV) with gas tamponade successfully prevents postoperative elevation of intraocular pressure (IOP). Methods: A prospective, controlled study was performed on patients who met inclusion criteria and underwent PPV with gas tamponade (SF6 18%-20% or C3F8 12%- 16%) over a 1-year period. Treatment eyes received topical aqueous suppressants at the end of surgery. Postoperative IOP checks were performed at 4 to 6 hours, 1 day, and 1 week. Results: Twenty-one control (C) and 20 treatment (T) eyes met the inclusion criteria. The IOP (in mm Hg) measured at 4 to 6 hours (23.05 [C], 14.73 [T]) and 1 day (23.24 [C], 17.28 [T]) postoperatively showed a statistically significant difference between the groups (P =.0038) at 4 to 6 hours, and a trend toward significance (P =.057) at 1 day. Eleven control and 3 treatment eyes had an IOP spike above 25 mm Hg at 4 to 6 hours or 1 day postoperatively (P =.02), and 6 control and 1 treatment eye had a postoperative IOP above 30 mm Hg. A pressure rise above 40 mm Hg was seen in 2 control eyes and no treatment eyes. Conclusions: Use of topical aqueous suppressants following PPV with long-acting gas tamponade is effective in preventing significant postoperative IOP elevation in a majority of cases.

Original languageEnglish (US)
Pages (from-to)143-154
Number of pages12
JournalTransactions of the American Ophthalmological Society
Volume96
StatePublished - 1998
Externally publishedYes

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Temazepam
Vitrectomy
Intraocular Pressure
Gases
Therapeutics
Prospective Studies
Pressure

ASJC Scopus subject areas

  • Ophthalmology

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The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation following pars plana vitrectomy with long-acting gas tamponade. / Mittra, R. A.; Pollack, J. S.; Dev, S.; Han, D. P.; Mieler, W. F.; Pulido, Jose S; Connor, T. B.; Weinstein, G. W.; Lichter, P. R.; Tornambe, P.; Elman, M.

In: Transactions of the American Ophthalmological Society, Vol. 96, 1998, p. 143-154.

Research output: Contribution to journalArticle

Mittra, R. A. ; Pollack, J. S. ; Dev, S. ; Han, D. P. ; Mieler, W. F. ; Pulido, Jose S ; Connor, T. B. ; Weinstein, G. W. ; Lichter, P. R. ; Tornambe, P. ; Elman, M. / The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation following pars plana vitrectomy with long-acting gas tamponade. In: Transactions of the American Ophthalmological Society. 1998 ; Vol. 96. pp. 143-154.
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abstract = "Purpose: To determine if topical aqueous suppressant therapy applied after pars plana vitrectomy (PPV) with gas tamponade successfully prevents postoperative elevation of intraocular pressure (IOP). Methods: A prospective, controlled study was performed on patients who met inclusion criteria and underwent PPV with gas tamponade (SF6 18{\%}-20{\%} or C3F8 12{\%}- 16{\%}) over a 1-year period. Treatment eyes received topical aqueous suppressants at the end of surgery. Postoperative IOP checks were performed at 4 to 6 hours, 1 day, and 1 week. Results: Twenty-one control (C) and 20 treatment (T) eyes met the inclusion criteria. The IOP (in mm Hg) measured at 4 to 6 hours (23.05 [C], 14.73 [T]) and 1 day (23.24 [C], 17.28 [T]) postoperatively showed a statistically significant difference between the groups (P =.0038) at 4 to 6 hours, and a trend toward significance (P =.057) at 1 day. Eleven control and 3 treatment eyes had an IOP spike above 25 mm Hg at 4 to 6 hours or 1 day postoperatively (P =.02), and 6 control and 1 treatment eye had a postoperative IOP above 30 mm Hg. A pressure rise above 40 mm Hg was seen in 2 control eyes and no treatment eyes. Conclusions: Use of topical aqueous suppressants following PPV with long-acting gas tamponade is effective in preventing significant postoperative IOP elevation in a majority of cases.",
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AU - Pollack, J. S.

AU - Dev, S.

AU - Han, D. P.

AU - Mieler, W. F.

AU - Pulido, Jose S

AU - Connor, T. B.

AU - Weinstein, G. W.

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AU - Tornambe, P.

AU - Elman, M.

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