The use of Roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease

Joseph Murphy, R. Scott Wright, Ihor Gussak, Brent Williams, Robert N. Daly, Valerie A. Cain, Henry J. Pieniaszek, Sherwin K.B. Sy, William Ebling, Kristen Simonson, Racehl A. Wilcox, Stephen L. Kopecky

Research output: Contribution to journalArticle

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Abstract

Introduction: Intravenous platelet glycoprotein (GP) IIb/IIIa receptor inhibitors have a significant beneficial impact on the outcomes of patients undergoing high-risk coronary interventions and in the stabilization of patients with unstable angina pectoris refractory to conventional medical treatment. The role of long-term treatment with oral platelet GP IIb/IIIa receptor inhibitors in patients with coronary artery disease is unproven. This study examined the dose-response effect on inhibition of platelet aggregation by roxifiban (DMP754), a novel oral platelet GP IIb/IIIa receptor inhibitor, and its safety and tolerability in patients with a history of chronic stable angina pectoris. Methods: Ninety-eight patients were randomized to receive either a placebo or 1 of 8 oral dosages of roxifiban. Twenty-two patients were enrolled in multiple-dose regimens, bringing the total study population to 120. The oral dosages were 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, or 2.5 mg/day for up to 30 days. Results: Pharmacodynamic response of roxifiban was clearly dose-dependent. Platelet aggregation inhibition in response to 10 μmol/L slope adenosine diphosphate was sustained throughout the study period (up to 1 month). No serious adverse events, including significant major bleeding events, were associated with roxifiban treatment. Minor bleeding was reported in 5% of participants in the placebo group (1 of 21 cases) versus 26% in the study group (26 of 99 cases). Incidence of minor bleeding associated with roxifiban 2 and 2.5 mg/day was significantly (p ≤ 0.05) greater than that with placebo. Adverse events, including gastrointestinal disorders, platelet and clotting disorders, and urinary tract disorders, were observed in 1 of 21 cases (5%) in the placebo group and in 12 of 99 cases (12%) in the study group. Reversible thrombocytopenia without other complications developed in two patients. Conclusions: Roxifiban-induced inhibition of platelet aggregation was dose-dependent and sustained throughout the study period: higher drug dosages correlated with higher levels of platelet inhibition and higher incidence of minor bleeding events. No serious adverse events were observed at any dosage. Thus, roxifiban appears to be a potent oral platelet GP IIb/IIIa receptor inhibitor that is clinically well-tolerated and deserves further study as a new treatment strategy in patients with chronic stable angina pectoris.

Original languageEnglish (US)
Pages (from-to)101-112
Number of pages12
JournalAmerican Journal of Cardiovascular Drugs
Volume3
Issue number2
DOIs
StatePublished - Jun 17 2003

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Integrin beta3
Platelet Glycoprotein GPIIb-IIIa Complex
Coronary Artery Disease
Stable Angina
Platelet Aggregation
Placebos
Hemorrhage
Blood Platelets
roxifiban acetate
roxifiban
Incidence
Unstable Angina
Therapeutics
Urinary Tract
Thrombocytopenia
Adenosine Diphosphate
Safety

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

The use of Roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease. / Murphy, Joseph; Wright, R. Scott; Gussak, Ihor; Williams, Brent; Daly, Robert N.; Cain, Valerie A.; Pieniaszek, Henry J.; Sy, Sherwin K.B.; Ebling, William; Simonson, Kristen; Wilcox, Racehl A.; Kopecky, Stephen L.

In: American Journal of Cardiovascular Drugs, Vol. 3, No. 2, 17.06.2003, p. 101-112.

Research output: Contribution to journalArticle

Murphy, J, Wright, RS, Gussak, I, Williams, B, Daly, RN, Cain, VA, Pieniaszek, HJ, Sy, SKB, Ebling, W, Simonson, K, Wilcox, RA & Kopecky, SL 2003, 'The use of Roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease', American Journal of Cardiovascular Drugs, vol. 3, no. 2, pp. 101-112. https://doi.org/10.2165/00129784-200303020-00004
Murphy, Joseph ; Wright, R. Scott ; Gussak, Ihor ; Williams, Brent ; Daly, Robert N. ; Cain, Valerie A. ; Pieniaszek, Henry J. ; Sy, Sherwin K.B. ; Ebling, William ; Simonson, Kristen ; Wilcox, Racehl A. ; Kopecky, Stephen L. / The use of Roxifiban (DMP754), a novel oral platelet glycoprotein IIb/IIIa receptor inhibitor, in patients with stable coronary artery disease. In: American Journal of Cardiovascular Drugs. 2003 ; Vol. 3, No. 2. pp. 101-112.
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AU - Williams, Brent

AU - Daly, Robert N.

AU - Cain, Valerie A.

AU - Pieniaszek, Henry J.

AU - Sy, Sherwin K.B.

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N2 - Introduction: Intravenous platelet glycoprotein (GP) IIb/IIIa receptor inhibitors have a significant beneficial impact on the outcomes of patients undergoing high-risk coronary interventions and in the stabilization of patients with unstable angina pectoris refractory to conventional medical treatment. The role of long-term treatment with oral platelet GP IIb/IIIa receptor inhibitors in patients with coronary artery disease is unproven. This study examined the dose-response effect on inhibition of platelet aggregation by roxifiban (DMP754), a novel oral platelet GP IIb/IIIa receptor inhibitor, and its safety and tolerability in patients with a history of chronic stable angina pectoris. Methods: Ninety-eight patients were randomized to receive either a placebo or 1 of 8 oral dosages of roxifiban. Twenty-two patients were enrolled in multiple-dose regimens, bringing the total study population to 120. The oral dosages were 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, or 2.5 mg/day for up to 30 days. Results: Pharmacodynamic response of roxifiban was clearly dose-dependent. Platelet aggregation inhibition in response to 10 μmol/L slope adenosine diphosphate was sustained throughout the study period (up to 1 month). No serious adverse events, including significant major bleeding events, were associated with roxifiban treatment. Minor bleeding was reported in 5% of participants in the placebo group (1 of 21 cases) versus 26% in the study group (26 of 99 cases). Incidence of minor bleeding associated with roxifiban 2 and 2.5 mg/day was significantly (p ≤ 0.05) greater than that with placebo. Adverse events, including gastrointestinal disorders, platelet and clotting disorders, and urinary tract disorders, were observed in 1 of 21 cases (5%) in the placebo group and in 12 of 99 cases (12%) in the study group. Reversible thrombocytopenia without other complications developed in two patients. Conclusions: Roxifiban-induced inhibition of platelet aggregation was dose-dependent and sustained throughout the study period: higher drug dosages correlated with higher levels of platelet inhibition and higher incidence of minor bleeding events. No serious adverse events were observed at any dosage. Thus, roxifiban appears to be a potent oral platelet GP IIb/IIIa receptor inhibitor that is clinically well-tolerated and deserves further study as a new treatment strategy in patients with chronic stable angina pectoris.

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