The use of radionuclide angiography in the diagnosis of coronary artery disease - A logistic regression analysis

R. J. Gibbons, K. L. Lee, D. Pryor, F. E. Harrell, R. E. Coleman, F. R. Cobb, R. A. Rosati, R. H. Jones

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The authors applied logistic regression analysis to a group of 736 patients with chest pain to determine which radionuclide angiographic (RNA) parameters were most useful in the diagnosis of significant coronary artery disease. The most useful parameters were exercise ejection fraction, exercise heart rate, 'ischemia score', and the presence of a regional wall motion abnormality at exercise. Ten clinical variables were used in one logistic regression model to estimate each patient's pretest probability of disease. A second logistic regression model considered these clinical variables and the four important RNA parameters to estimate each patient's posttest probability. These models were applied prospectively to a group of 76 patients with chest pain who did not have a high pretest probability of disease. Twenty-four patients (32%) could be diagnosed with 90% probability; 32 patients (42%) could be diagnosed with 85% probability. RNA testing is therefore helpful in the noninvasive diagnosis of coronary artery disease. However, a majority of patients who do have a low or intermediate pretest probability of disease will require additional testing for a definitive diagnosis.

Original languageEnglish (US)
Pages (from-to)740-746
Number of pages7
JournalUnknown Journal
Volume68
Issue number4
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint Dive into the research topics of 'The use of radionuclide angiography in the diagnosis of coronary artery disease - A logistic regression analysis'. Together they form a unique fingerprint.

  • Cite this

    Gibbons, R. J., Lee, K. L., Pryor, D., Harrell, F. E., Coleman, R. E., Cobb, F. R., Rosati, R. A., & Jones, R. H. (1983). The use of radionuclide angiography in the diagnosis of coronary artery disease - A logistic regression analysis. Unknown Journal, 68(4), 740-746. https://doi.org/10.1161/01.CIR.68.4.740