The use of photodynamic therapy for diseases of the esophagus

Seth A. Gross, Herbert C. Wolfsen

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

This is a review of the uses, history, and current status of photodynamic therapy for diseases of the esophagus, specifically Barrett's dysplasia and early esophageal carcinoma. This paper describes the clinical experience of photodynamic therapy and compares the use of various photosensitizer drugs. Finally, important biophotonics developments are discussed, including their anticipated impact for improved endoscopic detection of dysplasia and carcinoma. In addition, methods for real-time photodynamic therapy and light dosimetry are provided in order to optimize ablation treatment outcomes while minimizing the risk of complications.

Original languageEnglish (US)
Pages (from-to)5-21
Number of pages17
JournalJournal of Environmental Pathology, Toxicology and Oncology
Volume27
Issue number1
DOIs
StatePublished - 2008

Keywords

  • Aminolevulinic acid
  • Barrett's esophagus
  • Benzoporphyrin
  • Esophageal cancer
  • Motoxafin lutetium
  • Pheophorbides
  • Phthalocyanine
  • Porfimer sodium
  • Talaporfin
  • Temoporfin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

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