The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma

Robert Brown, Magdalena Zlatescu, Angelique Sijben, Gloria Roldan, Jay Easaw, Peter Forsyth, Ian Parney, Robert Sevick, Elizabeth Yan, Douglas Demetrick, David Schiff, Gregory Cairncross, Ross Mitchell

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Background: Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally. Methods: In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion of chromosomes 1p and 19q, a marker of good prognosis, could be predicted accurately by measuring image texture. Results: Differences in texture were seen between tumors with codeletion of chromosomes 1p and 19q and those with intact 1p and 19q alleles on contrast-enhanced T1-weighted and T2-weighted MR images. Quantitative MR texture on T2 images predicted codeletion of chromosomes 1p and 19q with high sensitivity and specificity. Conclusions: This new method of MR image interpretation may have the potential to augment the diagnostic assessment of patients with suspected low-grade glioma.

Original languageEnglish (US)
Pages (from-to)2357-2362
Number of pages6
JournalClinical Cancer Research
Volume14
Issue number8
DOIs
StatePublished - Apr 15 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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