The use of flow cytometry in diagnosis of paroxysmal nocturnal hemoglobinuria

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disease with complex pathophysiology, characterized by a global deficiency in glycosyl-phosphatidylinositol-anchored proteins in the affected cells. The name of the condition emphasizes the occurrence of complement-induced hemolysis due to lack of essential complement regulatory proteins in erythrocytes, particularly CD59. Over time, it became apparent that episodic exacerbations of chronic hemolytic anemia are not necessarily nocturnal, nor do they represent the main presenting symptom in all cases. Paroxysmal nocturnal hemoglobinuria can also manifest with thrombotic events and bone marrow failure, and distinguishing among different types of PNH is important for treatment and prognostic purposes.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalLaboratory medicine
Volume37
Issue number8
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Paroxysmal Hemoglobinuria
Flow cytometry
Flow Cytometry
Glycosylphosphatidylinositols
Stem cells
Bone
Proteins
Hemolytic Anemia
Hematopoietic Stem Cells
Hemolysis
Names
Complement System Proteins
Erythrocytes
Bone Marrow

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

The use of flow cytometry in diagnosis of paroxysmal nocturnal hemoglobinuria. / Olteanu, Horatiu; Xu, Yin.

In: Laboratory medicine, Vol. 37, No. 8, 01.01.2006, p. 498-502.

Research output: Contribution to journalReview article

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