The US smallpox vaccination program: A review of a large modern era smallpox vaccination implementation program

Gregory A. Poland, John D. Grabenstein, John M. Neff

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

We describe the US experience with a large-scale smallpox vaccination program in the modern era and quantify the anticipated and unanticipated local and systemic side-effects of smallpox vaccination. In addition, we review unexpected issues, such as the development of myopericarditis discovered during the implementation of this program. These results constitute the largest dataset of a vaccinia vaccination program utilizing calf-lymph derived New York City Board of Health strain vaccine (Dryvax, Wyeth) since the 1970s. These results should inform current and future vaccinia vaccination programs and provide a historical rate of complications against which candidate vaccine side-effects can be compared in future clinical trials.

Original languageEnglish (US)
Pages (from-to)2078-2081
Number of pages4
JournalVaccine
Volume23
Issue number17-18
DOIs
StatePublished - Mar 18 2005

Keywords

  • Smallpox
  • Smallpox vaccine
  • Smallpox vaccine side effects

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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