The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases

Consuelo M. López de Padilla, Timothy B. Niewold

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

There is increasing scientific and clinical interest in elucidating the biology of type I Interferons, which began approximately 60 years ago with the concept of "viral interference", a property that reduces the ability of a virus to infect cells. Although our understanding of the multiple cellular and molecular functions of interferons has advanced significantly, much remains to be learned and type I Interferons remain an active and fascinating area of inquiry. In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK-STAT) pathway and interferon regulatory factor pathway. We will also describe the role of type I interferons in autoimmune and inflammatory diseases, and its potential use as therapeutic agent.

Original languageEnglish (US)
Pages (from-to)14-21
Number of pages8
JournalGene
Volume576
Issue number1
DOIs
StatePublished - Jan 15 2016

Keywords

  • Autoimmune diseases
  • Idiopathic inflammatory myopathies
  • Interferon alpha
  • Interferon beta
  • Interferon signature
  • Multiple sclerosis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Genetics

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