The two faces of regulatory t cells in cancer

Nichole R. Blatner; Fotini Gounari; Khashayarsha Khazaie

doi:10.4161/onci.23852

The two faces of regulatory t cells in cancer

Nichole R. Blatner, Fotini Gounari, Khashayarsha Khazaie

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.

Original language	English (US)
Article number	e23852
Journal	OncoImmunology
Volume	2
Issue number	5
DOIs	https://doi.org/10.4161/onci.23852
State	Published - May 2013

Keywords

Colon-cancer
Inflammation
Polyposis
RORγt
Treg

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.23852

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AB - Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.

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KW - Inflammation

KW - Polyposis

KW - RORγt

KW - Treg

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The two faces of regulatory t cells in cancer

Abstract

Keywords

ASJC Scopus subject areas

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