The two faces of regulatory t cells in cancer

Nichole R. Blatner, Fotini Gounari, Khashayarsha Khazaie

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.

Original languageEnglish (US)
Article numbere23852
JournalOncoImmunology
Volume2
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Fingerprint

Colonic Neoplasms
Retinoids
Regulatory T-Lymphocytes
Neoplasms
Inflammation
T-Lymphocytes
Therapeutics

Keywords

  • Colon-cancer
  • Inflammation
  • Polyposis
  • RORγt
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

The two faces of regulatory t cells in cancer. / Blatner, Nichole R.; Gounari, Fotini; Khazaie, Khashayarsha.

In: OncoImmunology, Vol. 2, No. 5, e23852, 05.2013.

Research output: Contribution to journalArticle

Blatner, Nichole R. ; Gounari, Fotini ; Khazaie, Khashayarsha. / The two faces of regulatory t cells in cancer. In: OncoImmunology. 2013 ; Vol. 2, No. 5.
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