The two faces of regulatory t cells in cancer

Nichole R. Blatner, Fotini Gounari, Khashayarsha Khazaie

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.

Original languageEnglish (US)
Article numbere23852
JournalOncoImmunology
Volume2
Issue number5
DOIs
StatePublished - May 1 2013

Keywords

  • Colon-cancer
  • Inflammation
  • Polyposis
  • RORγt
  • Treg

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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