The Tumor Microenvironment Takes Center Stage in Ovarian Cancer Metastasis

Marion Curtis, Abir Mukherjee, Ernst Lengyel

Research output: Contribution to journalShort survey

7 Scopus citations


Historically, cancer has been studied at the genomic level with a focus on malignant cells. However, tumors are comprised of various host cells, which are co-opted by cancer cells to promote tumor growth and metastasis. Using multilevel analysis of human tumor biopsies, recent work identifies a reproducible 22-gene expression signature in the ovarian tumor microenvironment (TME) that correlates with disease progression and survival. These findings suggest that the TME is a promising therapeutic target that could be effective across a wide patient population, regardless of the genetic changes within their tumor cells.

Original languageEnglish (US)
Pages (from-to)517-519
Number of pages3
JournalTrends in Cancer
Issue number8
StatePublished - Aug 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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