@article{4e8f9b3add2c4e08987c32c325138e22,
title = "The Truth and Consequences of the COURAGE Trial",
abstract = "Percutaneous coronary intervention (PCI) has played an integral role in the therapeutic management strategies for patients who present with either acute coronary syndromes or stable angina pectoris. The COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial enrolled patients with chronic stable angina and at least 1 significant (≥70%) angiographic coronary stenosis who were randomly assigned to an initial treatment of either PCI in conjunction with optimal medical therapy or optimal medical therapy alone. Although the initial management strategy of PCI did not reduce the risk of death, myocardial infarction, or other major cardiovascular events, improvement in angina-free status and a reduction in the requirement for subsequent revascularization was observed. An in-depth analysis of the COURAGE trial design and execution is provided.",
author = "Kereiakes, {Dean J.} and Teirstein, {Paul S.} and Sarembock, {Ian J.} and Holmes, {David R.} and Krucoff, {Mitchell W.} and O'Neill, {William W.} and Ron Waksman and Williams, {David O.} and Popma, {Jeffrey J.} and Maurice Buchbinder and Roxana Mehran and Meredith, {Ian T.} and Moses, {Jeffrey W.} and Stone, {Gregg W.}",
note = "Funding Information: Dr. Kereiakes has received research grants from Pfizer, Conor Medsystems, Boston Scientific, Medtronic, Daiichi Sanyko, and Cordis Corp.; and consulting fees from Conor Medsystems, Cordis Corp., Core Valve, Eli Lilly & Co., Boston Scientific, and Abbott/Bioadsorbable Vascular Solutions. Dr. Teirstein has received research grants from Cordis, Boston Scientific, Abbott, and Conormed Systems; and royalties from Boston Scientific. Dr. Krucoff is a consultant for Abbott, Biosensors, Boston Scientific, Cordis J&J, Conor Medsystems, Medtronic, and Terumo; and has received research grants from Abbott, Biosensors, Boston Scientific, Cordis J&J, Conor Medsystems, Medtronic, and Terumo. Dr. Waksman is a consultant and has received speaker fees from Biotronik, Medtronic, and Boston Scientific; and has received research grants from Biotronik, Boston Scientific, Medicines Co., GlaxoSmithKline, Schering-Plough, and Sanofi-Aventis. Dr. Williams is a consultant for Cordis and Abbott Vascular; and has received research support from Cordis, Abbott Vascular, and Boston Scientific. Dr. Popma has received research grants from Cordis, Boston Scientific, Medtronic, Abbott, Ev3, and Biosensors; is on the advisory boards of Cordis, Boston Scientific, Medtronic, and Abbott; and is on the Speakers{\textquoteright} Bureau of Pfizer, Medicines Co., Bristol-Myers Squibb, and Sanofi-Aventis. Dr. Buchbinder has received consultant/research grants from Boston Scientific and Cordis. Dr. Mehran has received research grants from Medicines Co., Boston Scientific, and Cordis. Dr. Moses is a consultant for Cordis. Dr. Stone has received research grants from Boston Scientific and Abbott; has received consulting fees from Xtent, St. Jude Medical, and Medicines Co.; has received honoraria from Boston Scientific, Abbott, Medicines Co., Nycomed, and Medtronic; has equity interests in Devax and Xtent; and is on the Board of Directors of Devax.",
year = "2007",
month = oct,
day = "16",
doi = "10.1016/j.jacc.2007.07.063",
language = "English (US)",
volume = "50",
pages = "1598--1603",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "16",
}