TY - JOUR
T1 - The Triple-Code Model for Pancreatic Cancer
T2 - Cross Talk Among Genetics, Epigenetics, and Nuclear Structure
AU - Lomberk, Gwen A.
AU - Urrutia, Raul
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Pancreatic adenocarcinoma is painful, generally incurable, and frequently lethal. The current progression model indicates that this cancer evolves by mutations and deletions in key oncogenes and tumor suppressor genes. This article describes an updated, more comprehensive model that includes concepts from the fields of epigenetics and nuclear architecture. Widespread use of next-generation sequencing for identifying genetic and epigenetic changes genome-wide will help identify and validate more and better markers for this disease. Epigenetic alterations are amenable to pharmacologic manipulations, thus this new integrated paradigm will contribute to advance this field from a mechanistic and translational point of view.
AB - Pancreatic adenocarcinoma is painful, generally incurable, and frequently lethal. The current progression model indicates that this cancer evolves by mutations and deletions in key oncogenes and tumor suppressor genes. This article describes an updated, more comprehensive model that includes concepts from the fields of epigenetics and nuclear architecture. Widespread use of next-generation sequencing for identifying genetic and epigenetic changes genome-wide will help identify and validate more and better markers for this disease. Epigenetic alterations are amenable to pharmacologic manipulations, thus this new integrated paradigm will contribute to advance this field from a mechanistic and translational point of view.
KW - Epigenetics
KW - Pancreatic adenocarcinoma
KW - Triple-code hypothesis
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U2 - 10.1016/j.suc.2015.05.011
DO - 10.1016/j.suc.2015.05.011
M3 - Review article
C2 - 26315515
AN - SCOPUS:84940614230
SN - 0039-6109
VL - 95
SP - 935
EP - 952
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 5
ER -