The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure

Gwen A. Lomberk, Raul Urrutia

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Pancreatic adenocarcinoma is painful, generally incurable, and frequently lethal. The current progression model indicates that this cancer evolves by mutations and deletions in key oncogenes and tumor suppressor genes. This article describes an updated, more comprehensive model that includes concepts from the fields of epigenetics and nuclear architecture. Widespread use of next-generation sequencing for identifying genetic and epigenetic changes genome-wide will help identify and validate more and better markers for this disease. Epigenetic alterations are amenable to pharmacologic manipulations, thus this new integrated paradigm will contribute to advance this field from a mechanistic and translational point of view.

Original languageEnglish (US)
Pages (from-to)935-952
Number of pages18
JournalSurgical Clinics of North America
Volume95
Issue number5
DOIs
StatePublished - Oct 1 2015

Keywords

  • Epigenetics
  • Pancreatic adenocarcinoma
  • Triple-code hypothesis

ASJC Scopus subject areas

  • Surgery

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