The treatment of multiple myeloma using vincristine, carmustine, melphalan, cyclophosphamide, and prednisone (VBMCP) alternating with high-dose cyclophosphamide and α2β interferon versus VBMCP: Results of a Phase III Eastern Cooperative Oncology Group Study E5A93

Robert A. Kyle, Susanna Jacobus, William R. Friedenberg, Coenraad Frederik Slabber, S. Vincent Rajkumar, Philip R. Greipp

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

BACKGROUND: A randomized controlled trial tested the hypothesis that aggressive initial therapy using high-dose cyclophosphamide (HiCy) and α2β interferon (IFN) may be superior to standard combination alkylating agent regimens in the treatment of newly diagnosed myeloma. METHODS: This Eastern Cooperative Oncology Group trial evaluated 268 previously untreated patients with active multiple myeloma randomized to vincristine, carmustine, melphalan, cyclophosphamide, and prednisone (VBMCP) or VBMCP plus HiCy and recombinant IFN. RESULTS: The overall objective response was 62% in the VBMCP regimen and 68% in the VBMCP + HiCy + IFN group. The near complete response and complete response rates were 8.1% and 8.9%, respectively. Progression-free survival was 22.1 and 25.3 months, respectively. The median overall survival was 37.1 months for patients treated with VBMCP and 41.3 months for those treated with VBMCP + HiCy + IFN (P = .38). The 5-year overall survival rates were not significantly different between the 2 arms: 26.4% and 33%, respectively. Lethal toxicities occurred in 15 patients, including 10 from infection, but there was no significant difference in lethal toxicities between the 2 regimens. CONCLUSIONS: The study showed no significant benefit with the addition of HiCy and IFN to VBMCP.

Original languageEnglish (US)
Pages (from-to)2155-2164
Number of pages10
JournalCancer
Volume115
Issue number10
DOIs
StatePublished - May 15 2009

Keywords

  • Cyclophosphamide
  • Interferon
  • Myeloma
  • VBMCP

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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