The treatment of Graves' ophthalmopathy in an incidence cohort

G. B. Bartley, Vahab Fatourechi, E. F. Kadrmas, S. J. Jacobsen, D. M. Ilstrup, J. A. Garrity, C. A. Gorman

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine the frequencies of medical and surgical treatments in an incidence cohort of 120 patients with Graves' ophthalmopathy. METHODS: We reviewed the community medical records and administered a follow-up questionnaire. RESULTS: Of the 120 patients, 89 (74.2%) required either no therapy or only supportive measures. Six patients (5.0%) were treated with systemic corticosteroids. One patient had orbital radiotherapy. Twenty-four patients (20.0%) underwent one or more surgical procedures. The cumulative probabilities of undergoing ophthalmic surgery of any type were 5.0% by one year after the diagnosis of ophthalmopathy, 9.3% after two years, 15.9% after five years, and 21.8% after ten years. The need for surgery was significantly related to age (P < .01; Cox proportional hazards model) but was not significantly dependent on gender (P = .5) or the interaction of age and gender (P = .15). The overall risk of the need for surgery was 2.6 times greater in patients older than 50 years (95% confidence interval, 1.2 to 5.8) than in younger patients. There were no significant differences between tobacco smokers and nonsmokers in the cumulative probabilities of undergoing surgery. CONCLUSION: In 24 (20%) patients, one or more surgical procedures were used to treat Graves' ophthalmopathy. The probability of surgical intervention was significantly related to patient age (older than 50 years), but it was not related to gender or smoking.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalAmerican journal of ophthalmology
Volume121
Issue number2
DOIs
StatePublished - Jan 1 1996

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Graves Ophthalmopathy
Incidence
Therapeutics
Proportional Hazards Models
Tobacco
Medical Records
Adrenal Cortex Hormones
Radiotherapy
Smoking
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Bartley, G. B., Fatourechi, V., Kadrmas, E. F., Jacobsen, S. J., Ilstrup, D. M., Garrity, J. A., & Gorman, C. A. (1996). The treatment of Graves' ophthalmopathy in an incidence cohort. American journal of ophthalmology, 121(2), 200-206. https://doi.org/10.1016/S0002-9394(14)70585-9

The treatment of Graves' ophthalmopathy in an incidence cohort. / Bartley, G. B.; Fatourechi, Vahab; Kadrmas, E. F.; Jacobsen, S. J.; Ilstrup, D. M.; Garrity, J. A.; Gorman, C. A.

In: American journal of ophthalmology, Vol. 121, No. 2, 01.01.1996, p. 200-206.

Research output: Contribution to journalArticle

Bartley, GB, Fatourechi, V, Kadrmas, EF, Jacobsen, SJ, Ilstrup, DM, Garrity, JA & Gorman, CA 1996, 'The treatment of Graves' ophthalmopathy in an incidence cohort', American journal of ophthalmology, vol. 121, no. 2, pp. 200-206. https://doi.org/10.1016/S0002-9394(14)70585-9
Bartley, G. B. ; Fatourechi, Vahab ; Kadrmas, E. F. ; Jacobsen, S. J. ; Ilstrup, D. M. ; Garrity, J. A. ; Gorman, C. A. / The treatment of Graves' ophthalmopathy in an incidence cohort. In: American journal of ophthalmology. 1996 ; Vol. 121, No. 2. pp. 200-206.
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