The transcriptional repressor SNAIL is overexpressed in human colon cancer

Hemant K. Roy, Thomas Christopher Smyrk, Jennifer Koetsier, Thomas A. Victor, Ramesh K. Wali

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Abstract

Overexpression of the transcriptional repressor, SNAIL, has been implicated in the pathogenesis of a number of malignancies; however, there are no previous reports on the role of SNAIL in colorectal cancers (CRCs). We, therefore, evaluated human CRC specimens for the presence of the SNAIL protein. Immunohistochemical studies were performed using samples obtained from archived CRC paraffin blocks and a tissue array. Tissue sections were probed with a polyclonal antibody to human SNAIL and scored by a gastrointestinal pathologist. SNAIL was not detectable in uninvolved mucosa, but immunoreactivity was evident in 78% of tumors. SNAIL protein expression did not correlate with subsite location or gender, however, SNAIL-positive tumors had an older mean age (58.9 ± 12.7 versus 49.8 ± 127; P = 0.028). Furthermore, there was a trend that CRCs with metastatic ability more frequently overexpressed SNAIL (100 versus 65%; P = 0.11). In conclusion, we demonstrate, for the first time, that SNAIL is upregulated in human colon cancer, which potentially may have significance in control of metastasis and possibly serve as a target for chemopreventive agents.

Original languageEnglish (US)
Pages (from-to)42-46
Number of pages5
JournalDigestive Diseases and Sciences
Volume50
Issue number1
DOIs
StatePublished - Jan 2005

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Colonic Neoplasms
Colorectal Neoplasms
Neoplasms
Paraffin
Mucous Membrane
Proteins
Neoplasm Metastasis
Antibodies

Keywords

  • Colon cancer
  • Immunohistochemistry
  • Proto-oncogene
  • Transcription

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The transcriptional repressor SNAIL is overexpressed in human colon cancer. / Roy, Hemant K.; Smyrk, Thomas Christopher; Koetsier, Jennifer; Victor, Thomas A.; Wali, Ramesh K.

In: Digestive Diseases and Sciences, Vol. 50, No. 1, 01.2005, p. 42-46.

Research output: Contribution to journalArticle

Roy, Hemant K. ; Smyrk, Thomas Christopher ; Koetsier, Jennifer ; Victor, Thomas A. ; Wali, Ramesh K. / The transcriptional repressor SNAIL is overexpressed in human colon cancer. In: Digestive Diseases and Sciences. 2005 ; Vol. 50, No. 1. pp. 42-46.
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