The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner

Monica D. Nye, Luciana L. Almada, Maite G. Fernandez-Barrena, David L. Marks, Sherine F. Elsawa, Anne Vrabel, Ezequiel J. Tolosa, Volker Ellenrieder, Martin E Fernandez-Zapico

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The molecular mechanisms mediating the oncogenic activity of the transcription factor GLI1 remain elusive. Results: GLI1 interacts with SMAD factors and PCAF to regulate TGFβ-induced gene expression. Conclusion: These results define a novel epigenetic mechanism underlying the role of GLI1 as an oncogene. Significance: This study increases our understanding of gene expression regulation in cancer cells and its potential impact in tumor development.

Original languageEnglish (US)
Pages (from-to)15495-15506
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

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Gene expression regulation
Transforming Growth Factors
Gene expression
Tumors
Transcription Factors
Cells
Gene Expression
Gene Expression Regulation
Oncogenes
Epigenomics
Neoplasms
Proteins
p300-CBP-associated factor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. / Nye, Monica D.; Almada, Luciana L.; Fernandez-Barrena, Maite G.; Marks, David L.; Elsawa, Sherine F.; Vrabel, Anne; Tolosa, Ezequiel J.; Ellenrieder, Volker; Fernandez-Zapico, Martin E.

In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15495-15506.

Research output: Contribution to journalArticle

Nye, Monica D. ; Almada, Luciana L. ; Fernandez-Barrena, Maite G. ; Marks, David L. ; Elsawa, Sherine F. ; Vrabel, Anne ; Tolosa, Ezequiel J. ; Ellenrieder, Volker ; Fernandez-Zapico, Martin E. / The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 22. pp. 15495-15506.
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