The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner

Monica D. Nye, Luciana L. Almada, Maite G. Fernandez-Barrena, David L. Marks, Sherine F. Elsawa, Anne Vrabel, Ezequiel J. Tolosa, Volker Ellenrieder, Martin E. Fernandez-Zapico

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: The molecular mechanisms mediating the oncogenic activity of the transcription factor GLI1 remain elusive. Results: GLI1 interacts with SMAD factors and PCAF to regulate TGFβ-induced gene expression. Conclusion: These results define a novel epigenetic mechanism underlying the role of GLI1 as an oncogene. Significance: This study increases our understanding of gene expression regulation in cancer cells and its potential impact in tumor development.

Original languageEnglish (US)
Pages (from-to)15495-15506
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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