The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner

Monica D. Nye; Luciana L. Almada; Maite G. Fernandez-Barrena; David L. Marks; Sherine F. Elsawa; Anne Vrabel; Ezequiel J. Tolosa; Volker Ellenrieder; Martin E. Fernandez-Zapico

doi:10.1074/jbc.M113.545194

The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner

Monica D. Nye, Luciana L. Almada, Maite G. Fernandez-Barrena, David L. Marks, Sherine F. Elsawa, Anne Vrabel, Ezequiel J. Tolosa, Volker Ellenrieder, Martin E. Fernandez-Zapico

Oncology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: The molecular mechanisms mediating the oncogenic activity of the transcription factor GLI1 remain elusive. Results: GLI1 interacts with SMAD factors and PCAF to regulate TGFβ-induced gene expression. Conclusion: These results define a novel epigenetic mechanism underlying the role of GLI1 as an oncogene. Significance: This study increases our understanding of gene expression regulation in cancer cells and its potential impact in tumor development.

Original language	English (US)
Pages (from-to)	15495-15506
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.545194
State	Published - May 30 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Nye, M. D., Almada, L. L., Fernandez-Barrena, M. G., Marks, D. L., Elsawa, S. F., Vrabel, A., Tolosa, E. J., Ellenrieder, V., & Fernandez-Zapico, M. E. (2014). The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. Journal of Biological Chemistry, 289(22), 15495-15506. https://doi.org/10.1074/jbc.M113.545194

The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. / Nye, Monica D.; Almada, Luciana L.; Fernandez-Barrena, Maite G. et al.
In: Journal of Biological Chemistry, Vol. 289, No. 22, 30.05.2014, p. 15495-15506.

Research output: Contribution to journal › Article › peer-review

Nye, MD, Almada, LL, Fernandez-Barrena, MG, Marks, DL, Elsawa, SF, Vrabel, A, Tolosa, EJ, Ellenrieder, V & Fernandez-Zapico, ME 2014, 'The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner', Journal of Biological Chemistry, vol. 289, no. 22, pp. 15495-15506. https://doi.org/10.1074/jbc.M113.545194

Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A et al. The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. Journal of Biological Chemistry. 2014 May 30;289(22):15495-15506. doi: 10.1074/jbc.M113.545194

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abstract = "Background: The molecular mechanisms mediating the oncogenic activity of the transcription factor GLI1 remain elusive. Results: GLI1 interacts with SMAD factors and PCAF to regulate TGFβ-induced gene expression. Conclusion: These results define a novel epigenetic mechanism underlying the role of GLI1 as an oncogene. Significance: This study increases our understanding of gene expression regulation in cancer cells and its potential impact in tumor development.",

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The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner

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