The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Chaofan Li, Bibo Zhu, Young Min Son, Zheng Wang, Li Jiang, Min Xiang, Zhenqing Ye, Kathryn E. Beckermann, Yue Wu, James W. Jenkins, Peter J. Siska, Benjamin G. Vincent, Y. S. Prakash, Tobias Peikert, Brian T. Edelson, Reshma Taneja, Mark H. Kaplan, Jeffrey C. Rathmell, Haidong Dong, Taro HitosugiJie Sun

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The molecular regulation of CD8+ tissue-resident memory (Trm) cells and tumor-infiltrating lymphocytes (TILs) is incompletely understood. Li et al. report that the transcription factor Bhlhe40 was required for Trm cell and TIL mitochondrial fitness and epigenetic programming. They further identify an epigenetic regimen promoting TIL functional program for cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)491-507.e7
JournalImmunity
Volume51
Issue number3
DOIs
StatePublished - Sep 17 2019

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Keywords

  • acetate
  • Bhlhe40
  • epigenetic
  • metabolism
  • mitochondria
  • PD-L1
  • tissue resident memory T cell
  • Tubastatin A
  • tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Li, C., Zhu, B., Son, Y. M., Wang, Z., Jiang, L., Xiang, M., Ye, Z., Beckermann, K. E., Wu, Y., Jenkins, J. W., Siska, P. J., Vincent, B. G., Prakash, Y. S., Peikert, T., Edelson, B. T., Taneja, R., Kaplan, M. H., Rathmell, J. C., Dong, H., ... Sun, J. (2019). The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality. Immunity, 51(3), 491-507.e7. https://doi.org/10.1016/j.immuni.2019.08.013