The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease

Rohan De Silva, John Hardy, Juliana Crook, Naheed Khan, Elizabeth A. Graham, Christopher M. Morris, Nicholas W. Wood, Andrew J. Lees

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Mutations of the tau gene in frontotemporal dementia with parkinsonism and genetic association of the tau locus with progressive supranuclear palsy and corticobasal degeneration directly implicate the tau gene in the aetiology of these tauopathies. Three studies have also shown an association of the tau locus with clinically diagnosed Parkinson's disease. Noting the significant incidence of clinical misdiagnosis of Parkinson's disease, we investigated this tau gene association in a series of 157 pathologically confirmed cases of brain stem Lewy body Parkinson's disease by analysing their tau haplotype status. Although H1H1 homozygotes are elevated in the Parkinson's disease cases (63.1%) compared to controls (56.1%) this difference is not significant (P=0.22). These results indicate that any association must either be weak (with an odds ratio of less than 2) or that previous positive associations were due to contamination of clinically diagnosed cases with other diagnostic clinico-pathological entities such as neurofibrillary tangle Parkinson's syndrome.

Original languageEnglish (US)
Pages (from-to)201-203
Number of pages3
JournalNeuroscience Letters
Volume330
Issue number2
DOIs
StatePublished - Sep 20 2002

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Keywords

  • Genetics
  • Neurodegeneration
  • Parkinson's disease
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

De Silva, R., Hardy, J., Crook, J., Khan, N., Graham, E. A., Morris, C. M., Wood, N. W., & Lees, A. J. (2002). The tau locus is not significantly associated with pathologically confirmed sporadic Parkinson's disease. Neuroscience Letters, 330(2), 201-203. https://doi.org/10.1016/S0304-3940(02)00742-5