The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease

Naomi P. Visanji; Brit Mollenhauer; Thomas G. Beach; Charles H. Adler; Christopher S. Coffey; Catherine M. Kopil; Kuldip D. Dave; Tatiana Foroud; Lana Chahine; Danna Jennings

doi:10.2217/bmm-2016-0366

The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease

Naomi P. Visanji, Brit Mollenhauer, Thomas G. Beach, Charles H. Adler, Christopher S. Coffey, Catherine M. Kopil, Kuldip D. Dave, Tatiana Foroud, Lana Chahine, Danna Jennings

Neurology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.

Original language	English (US)
Pages (from-to)	359-368
Number of pages	10
Journal	Biomarkers in Medicine
Volume	11
Issue number	4
DOIs	https://doi.org/10.2217/bmm-2016-0366
State	Published - Apr 2017

Keywords

Biofluid
Biomarker
Parkinson's disease
Tissue
α-synuclein

ASJC Scopus subject areas

Drug Discovery
Clinical Biochemistry
Biochemistry, medical

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title = "The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease",

abstract = "The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.",

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AU - Adler, Charles H.

AU - Coffey, Christopher S.

AU - Kopil, Catherine M.

AU - Dave, Kuldip D.

AU - Foroud, Tatiana

AU - Chahine, Lana

AU - Jennings, Danna

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The Systemic Synuclein Sampling Study: Toward a biomarker for Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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