The synchronous presentation of non-hodgkin's lymphoma and pregnancy: A greater than ten-year follow-up

Thomas M. Habermann, Paul J. Kurtin, Keith L. Johansen, Michael C. Chen, Thomas E. Witzig, Joseph P. Colgan

Research output: Contribution to journalArticlepeer-review


Ten patients with concomitant active non-Hodgkin's lymphoma in pregnancy were evaluated from the years 1959 to 1989. The diagnosis of lymphoma was established in first trimester ( 1), in the second trimester (5), in the third trimester (1 ), at the time of delivery with placental involvement (1), and immediate postpartum (2). The median age at the time of diagnosis of lymphoma was 31 years (23 to 35). The maternal median survival from the time of diagnosis was 9.5 years (range 1.8 to 27). Tissue was reviewed and classified according to the World Health Classification of Lymphomas. There were two follicular grade 1, four diffuse large B-cell, two peripheral T-cell unspecified type, one follicular grade 3, and one composite lymphoma (follicular lymphoma grade 2 and Hodgkin's lymphoma, nodular sclerosis type). Two patients presented with central nervous system disease. One patient presented with parenchymal disease and died at 4.5 years, and the other patient with spinal fluid involvement is alive and disease-free at 15.2 years. Of the patients with follicular disease, one patient died 8.9 years from diagnosis, and one patient is alive and disease-free 27 years from diagnosis. From 1980 to 1989, five patients were diagnosed with follicular large cell, diffuse large cell and peripheral T-cell non-Hodgkin' s lymphoma and completed therapy. All five patients achieved a complete remission, and three are alive and disease-free with a median follow-up of 13.5 years (9.6 to 15.2). Eleven fetuses were delivered without complications. There was one spontaneous abortion. There were no congenital anomalies. One patient with follicular lymphoma had two more pregnancies after her diagnosis of lymphoma, one full-term infant and another spontaneous abortion. Through varied therapeutic programs, the management of mother and fetus can ensure a successful long-term outcome.

Original languageEnglish (US)
Pages (from-to)224b
Issue number11 PART II
StatePublished - Dec 1 2000

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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