The SWI/SNF complex and cancer

D. Reisman, S. Glaros, E. A. Thompson

Research output: Contribution to journalReview article

407 Scopus citations

Abstract

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

Original languageEnglish (US)
Pages (from-to)1653-1668
Number of pages16
JournalOncogene
Volume28
Issue number14
DOIs
StatePublished - Apr 9 2009

    Fingerprint

Keywords

  • BAF47
  • BRG1
  • BRM
  • Chromatin remodeling
  • Tumor suppressor

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this