Abstract
The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
Original language | English (US) |
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Pages (from-to) | 1653-1668 |
Number of pages | 16 |
Journal | Oncogene |
Volume | 28 |
Issue number | 14 |
DOIs | |
State | Published - Apr 9 2009 |
Keywords
- BAF47
- BRG1
- BRM
- Chromatin remodeling
- Tumor suppressor
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research