TY - JOUR
T1 - The Stretta procedure for the treatment of GERD
T2 - 6 and 12 month follow-up of the U.S. Open label trial
AU - Triadafilopoulos, George
AU - DiBaise, John K.
AU - Nostrant, Timothy T.
AU - Stollman, Neil H.
AU - Anderson, Paul K.
AU - Wolfe, M. Michael
AU - Rothstein, Richard I.
AU - Wo, John M.
AU - Corley, Douglas A.
AU - Patti, Marco G.
AU - Antignano, Louis V.
AU - Goff, John S.
AU - Edmundowicz, Steven A.
AU - Castell, Donald O.
AU - Rabine, John C.
AU - Kim, Michael S.
AU - Utley, David S.
PY - 2002
Y1 - 2002
N2 - Background: This multicenter prospective study investigated the longer-term (12 month) safety and efficacy of radiofrequency energy delivery for the treatment of GERD. Methods: A prospective study was conducted of 118 patients with chronic heartburn and/or regurgitation who required antisecretory medication daily and had demonstrated pathologic esophageal acid exposure, a sliding hiatal hernia (≤2 cm), and esophagitis (≤ grade 2). RF energy was delivered with the Stretta catheter and thermocouple-controlled generator to create thermal lesions below the mucosa at the gastroesophageal junction. GERD symptom scores, quality of life (SF-36), and medication use were assessed at 0, 1, 4, 6, and 12 months; esophageal acid exposure, motility, and endoscopy were assessed at 0 and 6 months. Results: Seventy-two men and 46 women were treated. At 12 months, 94 patients were available for follow-up. There were improvements after 12 months in the median heartburn score (4 to 1, p = 0.0001), GERD score (27 to 9, p = 0.0001), satisfaction (1 to 4, p = 0.0001), mental SF-36 (46.3 to 55.4, p < 0.0001), and physical SF-36 (40.9 to 53.1, p = 0.0001); proton pump inhibitor requirement fell from 88.1% to 30% of patients. Esophageal acid exposure improved significantly (10.2% to 6.4%, p = 0.0001). There were 10 (8.6%) complications, none of which required therapeutic intervention. Conclusion: The Stretta procedure significantly improves GERD symptoms, quality of life, and esophageal acid exposure and eliminates the need for antisecretory medication in the majority of patients at 12 months.
AB - Background: This multicenter prospective study investigated the longer-term (12 month) safety and efficacy of radiofrequency energy delivery for the treatment of GERD. Methods: A prospective study was conducted of 118 patients with chronic heartburn and/or regurgitation who required antisecretory medication daily and had demonstrated pathologic esophageal acid exposure, a sliding hiatal hernia (≤2 cm), and esophagitis (≤ grade 2). RF energy was delivered with the Stretta catheter and thermocouple-controlled generator to create thermal lesions below the mucosa at the gastroesophageal junction. GERD symptom scores, quality of life (SF-36), and medication use were assessed at 0, 1, 4, 6, and 12 months; esophageal acid exposure, motility, and endoscopy were assessed at 0 and 6 months. Results: Seventy-two men and 46 women were treated. At 12 months, 94 patients were available for follow-up. There were improvements after 12 months in the median heartburn score (4 to 1, p = 0.0001), GERD score (27 to 9, p = 0.0001), satisfaction (1 to 4, p = 0.0001), mental SF-36 (46.3 to 55.4, p < 0.0001), and physical SF-36 (40.9 to 53.1, p = 0.0001); proton pump inhibitor requirement fell from 88.1% to 30% of patients. Esophageal acid exposure improved significantly (10.2% to 6.4%, p = 0.0001). There were 10 (8.6%) complications, none of which required therapeutic intervention. Conclusion: The Stretta procedure significantly improves GERD symptoms, quality of life, and esophageal acid exposure and eliminates the need for antisecretory medication in the majority of patients at 12 months.
UR - http://www.scopus.com/inward/record.url?scp=0036481501&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036481501&partnerID=8YFLogxK
U2 - 10.1067/mge.2002.121227
DO - 10.1067/mge.2002.121227
M3 - Article
C2 - 11818914
AN - SCOPUS:0036481501
SN - 0016-5107
VL - 55
SP - 149
EP - 156
JO - Gastrointestinal endoscopy
JF - Gastrointestinal endoscopy
IS - 2
ER -