The stress of lung aging: Endoplasmic reticulum and senescence tête-à-tête

M. L.Koloko Ngassie; C. A. Brandsma; R. Gosens; Y. S. Prakash; J. K. Burgess

doi:10.1152/PHYSIOL.00039.2020

The stress of lung aging: Endoplasmic reticulum and senescence tête-à-tête

M. L.Koloko Ngassie, C. A. Brandsma, R. Gosens, Y. S. Prakash, J. K. Burgess

Anesthesiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.

Original language	English (US)
Pages (from-to)	150-159
Number of pages	10
Journal	Physiology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1152/PHYSIOL.00039.2020
State	Published - 2021

Keywords

COPD
Cellular senescence
Endoplasmic reticulum stress
Lung aging
Unfolded protein response

ASJC Scopus subject areas

Physiology

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10.1152/PHYSIOL.00039.2020

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title = "The stress of lung aging: Endoplasmic reticulum and senescence t{\^e}te-{\`a}-t{\^e}te",

abstract = "Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.",

keywords = "COPD, Cellular senescence, Endoplasmic reticulum stress, Lung aging, Unfolded protein response",

author = "Ngassie, {M. L.Koloko} and Brandsma, {C. A.} and R. Gosens and Prakash, {Y. S.} and Burgess, {J. K.}",

note = "Publisher Copyright: {\textcopyright} 2021 Int. Union Physiol. Sci./Am. Physiol. Soc.",

year = "2021",

doi = "10.1152/PHYSIOL.00039.2020",

language = "English (US)",

volume = "36",

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T1 - The stress of lung aging

T2 - Endoplasmic reticulum and senescence tête-à-tête

AU - Ngassie, M. L.Koloko

AU - Brandsma, C. A.

AU - Gosens, R.

AU - Prakash, Y. S.

AU - Burgess, J. K.

PY - 2021

Y1 - 2021

N2 - Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.

AB - Beyond the structural changes, features including the dysregulation of endoplasmic reticulum (ER) stress response and increased senescence characterize the lung aging. ER stress response and senescence have been reported to be induced by factors like cigarette smoke. Therefore, deciphering the mechanisms underlying ER and senescent pathways interaction has become a challenge. In this review we highlight the known and unknown regarding ER stress response and senescence and their cross talk in aged lung.

KW - COPD

KW - Cellular senescence

KW - Endoplasmic reticulum stress

KW - Lung aging

KW - Unfolded protein response

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EP - 159

JO - Physiology

JF - Physiology

IS - 3

ER -

The stress of lung aging: Endoplasmic reticulum and senescence tête-à-tête

Abstract

Keywords

ASJC Scopus subject areas

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