The stress axis gone awry: A possible neuroendocrine explanation for increased risk of completed suicide

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

While the dexamethasone suppression test (DST) has not proven useful as a diagnostic test for "true" depression, it shows increasing promise as a potential indicator of psychiatric patients at increased risk for suicide. An indicator of the activity level of the hypothalamic-pituitary-adrenal (HPA) axis, the DST is an endocrine test that has caught the interest of psychiatric researchers throughout the last century because of the role of the HPA axis in managing an organism's homeostasis and stress response. This article will present a brief literature review of the role of the DST in psychiatry. It will propose a hypothesis, supported by data from two recent small studies, that suggests that chronic overdrive in the HPA axis, as manifested in a nonsuppressing DST, may result in an increased likelihood of suicide when the individual is acutely stressed.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalPrimary Psychiatry
Volume12
Issue number5
StatePublished - May 1 2005

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Suicide
Dexamethasone
Psychiatry
Routine Diagnostic Tests
Homeostasis
Research Personnel
Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Genetics

Cite this

The stress axis gone awry : A possible neuroendocrine explanation for increased risk of completed suicide. / Bostwick, J. Michael.

In: Primary Psychiatry, Vol. 12, No. 5, 01.05.2005, p. 49-52.

Research output: Contribution to journalReview article

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