The Stem-Loop Structure of the cis-Encapsidation Signal Is Highly Conserved in Naturally Occurring Hepatitis B Virus Variants

Tomasz Laskus, Jorge Rakela, David H. Persing

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The region encoding the stem-loop structure of the HBV cis -encapsidation signal was sequenced in 87 patients with various forms of hepatitis. Altogether, 20 nucleotide substitutions were found; 15/20 were predicted to increase the stability of the stem-loop structure. Substitutions likely to decrease the stability of the cis-encapsidation signal were not observed.

Original languageEnglish (US)
Article number71247
Pages (from-to)809-812
Number of pages4
JournalVirology
Volume200
Issue number2
DOIs
StatePublished - May 1 1994

ASJC Scopus subject areas

  • Virology

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