Abstract
The SLC4 family consists of 10 genes (SLC4A1-5; SLC4A7-11). All encode integral membrane proteins with very similar hydropathy plots - consistent with 10-14 transmembrane segments. Nine SLC4 members encode proteins that transport HCO3- (or a related species, such as CO32-) across the plasma membrane. Functionally, eight of these proteins fall into two major groups: three Cl-HCO3 exchangers (AE1-3) and five Na+-coupled HCO3- transporters (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE). Two of the Na +-coupled transporters (NBCe1, NBCe2) are electrogenic; the other three Na+-coupled HCO3- transporters and all three AEs are electroneutral. In addition, two other SLC4 members (AE4, SLC4A9 and BTR1, SLC4A11) do not yet have a firmly established function. Most, though not all, SLC4 members are functionally inhibited by 4,4′-diisothiocyanatostilbene- 2,2′-disulfonate (DIDS). SLC4 proteins play important roles many modes of acid-base homeostasis: the carriage of CO2 by erythrocytes, the transport of H+ or HCO3- by several epithelia, as well as the regulation of cell volume and intracellular pH.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-182 |
| Number of pages | 24 |
| Journal | Molecular Aspects of Medicine |
| Volume | 34 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Apr 2013 |
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Keywords
- Bicarbonate
- Boron
- Carbonate
- Chloride
- Cotransporter
- Exchanger
- SLC4
- Sodium
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Molecular Medicine
- Clinical Biochemistry
- Medicine(all)
Cite this
The SLC4 family of bicarbonate (HCO3 -) transporters. / Romero, Michael F; Chen, An Ping; Parker, Mark D.; Boron, Walter F.
In: Molecular Aspects of Medicine, Vol. 34, No. 2-3, 04.2013, p. 159-182.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The SLC4 family of bicarbonate (HCO3 -) transporters
AU - Romero, Michael F
AU - Chen, An Ping
AU - Parker, Mark D.
AU - Boron, Walter F.
PY - 2013/4
Y1 - 2013/4
N2 - The SLC4 family consists of 10 genes (SLC4A1-5; SLC4A7-11). All encode integral membrane proteins with very similar hydropathy plots - consistent with 10-14 transmembrane segments. Nine SLC4 members encode proteins that transport HCO3- (or a related species, such as CO32-) across the plasma membrane. Functionally, eight of these proteins fall into two major groups: three Cl-HCO3 exchangers (AE1-3) and five Na+-coupled HCO3- transporters (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE). Two of the Na +-coupled transporters (NBCe1, NBCe2) are electrogenic; the other three Na+-coupled HCO3- transporters and all three AEs are electroneutral. In addition, two other SLC4 members (AE4, SLC4A9 and BTR1, SLC4A11) do not yet have a firmly established function. Most, though not all, SLC4 members are functionally inhibited by 4,4′-diisothiocyanatostilbene- 2,2′-disulfonate (DIDS). SLC4 proteins play important roles many modes of acid-base homeostasis: the carriage of CO2 by erythrocytes, the transport of H+ or HCO3- by several epithelia, as well as the regulation of cell volume and intracellular pH.
AB - The SLC4 family consists of 10 genes (SLC4A1-5; SLC4A7-11). All encode integral membrane proteins with very similar hydropathy plots - consistent with 10-14 transmembrane segments. Nine SLC4 members encode proteins that transport HCO3- (or a related species, such as CO32-) across the plasma membrane. Functionally, eight of these proteins fall into two major groups: three Cl-HCO3 exchangers (AE1-3) and five Na+-coupled HCO3- transporters (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE). Two of the Na +-coupled transporters (NBCe1, NBCe2) are electrogenic; the other three Na+-coupled HCO3- transporters and all three AEs are electroneutral. In addition, two other SLC4 members (AE4, SLC4A9 and BTR1, SLC4A11) do not yet have a firmly established function. Most, though not all, SLC4 members are functionally inhibited by 4,4′-diisothiocyanatostilbene- 2,2′-disulfonate (DIDS). SLC4 proteins play important roles many modes of acid-base homeostasis: the carriage of CO2 by erythrocytes, the transport of H+ or HCO3- by several epithelia, as well as the regulation of cell volume and intracellular pH.
KW - Bicarbonate
KW - Boron
KW - Carbonate
KW - Chloride
KW - Cotransporter
KW - Exchanger
KW - SLC4
KW - Sodium
UR - http://www.scopus.com/inward/record.url?scp=84875182780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875182780&partnerID=8YFLogxK
U2 - 10.1016/j.mam.2012.10.008
DO - 10.1016/j.mam.2012.10.008
M3 - Article
VL - 34
SP - 159
EP - 182
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
SN - 0098-2997
IS - 2-3
ER -