TY - JOUR
T1 - The sirolimus-eluting cypher select coronary stent for the treatment of bare-metal and drug-eluting stent restenosis
T2 - Insights from the e-select 64-71 (multicenter post-market surveillance) registry
AU - Abizaid, Alexandre
AU - Costa, J. Ribamar
AU - Banning, Adrian
AU - Bartorelli, Antonio L.
AU - Dzavik, Vladimir
AU - Ellis, Stephen
AU - Gao, Runlin
AU - Holmes, David R.
AU - Jeong, Muyng Ho
AU - Legrand, Victor
AU - Neumann, Franz Josef
AU - Nyakern, Maria
AU - Orlick, Amy
AU - Spaulding, Christian
AU - Worthley, Stephen
AU - Urban, Philip M.
N1 - Funding Information:
Dr. Banning has received research funding from Boston Scientific and Cordis Corporation. Dr. Bartorelli is a member of the scientific advisory board of Abbott Vascular. Dr. Dzavik is a consultant for Abbott Vascular and has received educational funds from Cordis Corporation. Dr. Legrand is a consultant for Cordis Corporation and a member of the scientific advisory board of Abbott Vascular, and has a consultancy agreement with Johnson & Johnson. Dr. Nyakern is a salaried consultant for Cordis Corporation, Johnson and Johnson. Ms. Orlick is an employee of Cordis Corporation. Dr. Spaulding has received research funding from Cordis Corporation, Abbott Vascular, Stentys, and Eli Lilly; has received speaker fees from Cordis Corporation, Eli Lilly, Pfizer Inc.; was on the scientific advisory board of Cordis Corporation; and has been a full-time employee of Cordis Corporation since July 1, 2010. Dr. Urban is a consultant for Cordis Corporation, Johnson & Johnson and for Biosensors International, and received speaker fees from Terumo. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
PY - 2012/1
Y1 - 2012/1
N2 - This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselected, real-world patients. There is paucity of consistent data on DES for the treatment of ISR, especially, DES ISR. The e-SELECT (Multicenter Post-Market Surveillance) registry is a Web-based, multicenter and international registry encompassing virtually all subsets of patients and lesions treated with at least 1 SES during the period from 2006 to 2008. We enrolled in this pre-specified subanalysis all patients with at least 1 clinically relevant BMS or DES ISR treated with SES. Primary endpoint was major adverse cardiac events and stent thrombosis rate at 1 year. Of 15,147 patients enrolled, 1,590 (10.5%) presented at least 1 ISR (BMS group, n = 1,235, DES group, n = 355). Patients with DES ISR had higher incidence of diabetes (39.4% vs. 26.9%, p < 0.001), renal insufficiency (5.8% vs. 2.3%, p = 0.003), and prior coronary artery bypass graft (20.5% vs. 11.8%, p < 0.001). At 1 year, death (1.4% for BMS vs. 2.1% for DES, p = 0.3) and myocardial infarction (2.4% for BMS and 3.3% for DES, p = 0.3) rates were similar, whereas ischemia-driven target lesion revascularization and definite/probable late stent thrombosis were higher in patients with DES ISR (6.9% vs. 3.1%, p = 0.003, and 1.8% vs. 0.5%, p = 0.04, respectively). Use of SES for either BMS or DES ISR treatment is safe and associated with low target lesion revascularization recurrence and no apparent safety concern.
AB - This study sought to compare the 1-year safety and efficacy of Cypher Select or Cypher Select Plus (Cordis Corporation, Bridgewater, New Jersey) sirolimus-eluting stents (SES) with the treatment of bare-metal stents (BMS) and drug-eluting stent (DES) in-stent restenosis (ISR) in nonselected, real-world patients. There is paucity of consistent data on DES for the treatment of ISR, especially, DES ISR. The e-SELECT (Multicenter Post-Market Surveillance) registry is a Web-based, multicenter and international registry encompassing virtually all subsets of patients and lesions treated with at least 1 SES during the period from 2006 to 2008. We enrolled in this pre-specified subanalysis all patients with at least 1 clinically relevant BMS or DES ISR treated with SES. Primary endpoint was major adverse cardiac events and stent thrombosis rate at 1 year. Of 15,147 patients enrolled, 1,590 (10.5%) presented at least 1 ISR (BMS group, n = 1,235, DES group, n = 355). Patients with DES ISR had higher incidence of diabetes (39.4% vs. 26.9%, p < 0.001), renal insufficiency (5.8% vs. 2.3%, p = 0.003), and prior coronary artery bypass graft (20.5% vs. 11.8%, p < 0.001). At 1 year, death (1.4% for BMS vs. 2.1% for DES, p = 0.3) and myocardial infarction (2.4% for BMS and 3.3% for DES, p = 0.3) rates were similar, whereas ischemia-driven target lesion revascularization and definite/probable late stent thrombosis were higher in patients with DES ISR (6.9% vs. 3.1%, p = 0.003, and 1.8% vs. 0.5%, p = 0.04, respectively). Use of SES for either BMS or DES ISR treatment is safe and associated with low target lesion revascularization recurrence and no apparent safety concern.
KW - in-stent restenosis
KW - sirolimus-eluting stent(s)
KW - target lesion revascularization
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U2 - 10.1016/j.jcin.2011.09.016
DO - 10.1016/j.jcin.2011.09.016
M3 - Article
C2 - 22230152
AN - SCOPUS:84855605315
SN - 1936-8798
VL - 5
SP - 64
EP - 71
JO - JACC: Cardiovascular Interventions
JF - JACC: Cardiovascular Interventions
IS - 1
ER -