The significance of isolated Y chromosome loss in bone marrow metaphase cells from males over age 50 years

Anne E. Wiktor, Daniel L. van Dyke, Janice M. Hodnefield, Jeanette Eckel-Passow, Curtis A. Hanson

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

To further investigate the potential clinical significance of Y chromosome loss as the sole bone marrow karyotype change, we studied 161 Mayo Clinic male patients with 75% or more metaphase cells with Y loss, and correlated the percent Y loss with age and hematopathologic review. In patients with a lymphoproliferative or plasma cell disorder, the negligible proportion of bone marrow involvement cannot account for the observed high proportion of -Y cells. In males with myeloid disease, Y loss appears to often represent the abnormal myeloid clone, which may also harbor acquired genetic changes that are not observed by conventional cytogenetic analysis.

Original languageEnglish (US)
Pages (from-to)1297-1300
Number of pages4
JournalLeukemia Research
Volume35
Issue number10
DOIs
StatePublished - Oct 1 2011

Keywords

  • Acute myeloid leukemia
  • Cytogenetics
  • Myelodysplasia
  • Y chromosome loss

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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