TY - JOUR
T1 - The Second Canadian Conference on Multiple Sclerosis
AU - Weinshenker, Brian G.
AU - Nelson, Robert
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990/2
Y1 - 1990/2
N2 - The epidemiology of multiple sclerosis (MS) and the planning and interpretation of clinical therapeutic trials were the subjects of a symposium on MS held on June 13, 1989. Several speakers addressed whether MS is a genetic or an environmental disease. An environmental trigger would resolve the relatively low penetrance of the disease in susceptible individuals, although the alternative hypothesis that MS is a multigenic disease would also account for this observation. Clinical trials have to date failed to confirm the efficacy of any immunosuppressive or other agent in the management of progressive MS. Magnetic resonance imaging (MRI) appears to be highly sensitive for monitoring the activity of MS. Preliminary evidence suggests that MRI activity correlates with longitudinal clinical assessments of disability. Immunologic tests, while valuable in determining pathophysiology of MS, have not been strongly correlated with clinical outcome.
AB - The epidemiology of multiple sclerosis (MS) and the planning and interpretation of clinical therapeutic trials were the subjects of a symposium on MS held on June 13, 1989. Several speakers addressed whether MS is a genetic or an environmental disease. An environmental trigger would resolve the relatively low penetrance of the disease in susceptible individuals, although the alternative hypothesis that MS is a multigenic disease would also account for this observation. Clinical trials have to date failed to confirm the efficacy of any immunosuppressive or other agent in the management of progressive MS. Magnetic resonance imaging (MRI) appears to be highly sensitive for monitoring the activity of MS. Preliminary evidence suggests that MRI activity correlates with longitudinal clinical assessments of disability. Immunologic tests, while valuable in determining pathophysiology of MS, have not been strongly correlated with clinical outcome.
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U2 - 10.1017/S0317167100030031
DO - 10.1017/S0317167100030031
M3 - Article
C2 - 2311018
AN - SCOPUS:0025361253
SN - 0317-1671
VL - 17
SP - 53
EP - 60
JO - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
JF - Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
IS - 1
ER -