The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost

C. R. Arnt, Scott H Kaufmann

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.

Original languageEnglish (US)
Pages (from-to)1118-1120
Number of pages3
JournalCell Death and Differentiation
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2003

Fingerprint

Apoptosis
Peptides
Pharmaceutical Preparations
Neoplasms
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology

Cite this

The saintly side of Smac/DIABLO : Giving anticancer drug-induced apoptosis a boost. / Arnt, C. R.; Kaufmann, Scott H.

In: Cell Death and Differentiation, Vol. 10, No. 10, 01.10.2003, p. 1118-1120.

Research output: Contribution to journalArticle

@article{c500af0656ed4fc0add40688ac76df54,
title = "The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost",
abstract = "In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.",
author = "Arnt, {C. R.} and Kaufmann, {Scott H}",
year = "2003",
month = "10",
day = "1",
doi = "10.1038/sj.cdd.4401294",
language = "English (US)",
volume = "10",
pages = "1118--1120",
journal = "Cell Death and Differentiation",
issn = "1350-9047",
publisher = "Nature Publishing Group",
number = "10",

}

TY - JOUR

T1 - The saintly side of Smac/DIABLO

T2 - Giving anticancer drug-induced apoptosis a boost

AU - Arnt, C. R.

AU - Kaufmann, Scott H

PY - 2003/10/1

Y1 - 2003/10/1

N2 - In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.

AB - In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.

UR - http://www.scopus.com/inward/record.url?scp=0141962476&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141962476&partnerID=8YFLogxK

U2 - 10.1038/sj.cdd.4401294

DO - 10.1038/sj.cdd.4401294

M3 - Article

C2 - 14502234

AN - SCOPUS:0141962476

VL - 10

SP - 1118

EP - 1120

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

SN - 1350-9047

IS - 10

ER -