Abstract
In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1118-1120 |
| Number of pages | 3 |
| Journal | Cell Death and Differentiation |
| Volume | 10 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2003 |
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ASJC Scopus subject areas
- Cell Biology
Cite this
The saintly side of Smac/DIABLO : Giving anticancer drug-induced apoptosis a boost. / Arnt, C. R.; Kaufmann, Scott H.
In: Cell Death and Differentiation, Vol. 10, No. 10, 01.10.2003, p. 1118-1120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The saintly side of Smac/DIABLO
T2 - Giving anticancer drug-induced apoptosis a boost
AU - Arnt, C. R.
AU - Kaufmann, Scott H
PY - 2003/10/1
Y1 - 2003/10/1
N2 - In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.
AB - In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.
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UR - http://www.scopus.com/inward/citedby.url?scp=0141962476&partnerID=8YFLogxK
U2 - 10.1038/sj.cdd.4401294
DO - 10.1038/sj.cdd.4401294
M3 - Article
C2 - 14502234
AN - SCOPUS:0141962476
VL - 10
SP - 1118
EP - 1120
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
SN - 1350-9047
IS - 10
ER -