The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost

C. R. Arnt, Scott H. Kaufmann

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.

Original languageEnglish (US)
Pages (from-to)1118-1120
Number of pages3
JournalCell Death and Differentiation
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost'. Together they form a unique fingerprint.

Cite this