The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost

C. R. Arnt; Scott H. Kaufmann

doi:10.1038/sj.cdd.4401294

The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost

C. R. Arnt, Scott H. Kaufmann

Oncology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.

Original language	English (US)
Pages (from-to)	1118-1120
Number of pages	3
Journal	Cell Death and Differentiation
Volume	10
Issue number	10
DOIs	https://doi.org/10.1038/sj.cdd.4401294
State	Published - Oct 1 2003

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/sj.cdd.4401294

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title = "The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost",

abstract = "In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.",

author = "Arnt, {C. R.} and Kaufmann, {Scott H.}",

note = "Funding Information: We thank Greg Gores, Mike Chiorean, Michael Heldebrant, Wei Meng and Bill Earnshaw for stimulating discussions and Deb Strauss for editorial assistance. Supported in part by a grant from the NIH (R01 CA69008) and a predoctoral fellowship to CRA from the Mayo Foundation for Education and Research.",

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AB - In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.

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The saintly side of Smac/DIABLO: Giving anticancer drug-induced apoptosis a boost

Abstract

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