Abstract
In summary, recent studies have suggested that Smac-based peptides are capable of enhancing the cytotoxicity of chemotherapeutic agents in a variety of tumor cells in vitro and in vivo. These studies also suggest that Smac activity might be deficient in tumor cells, providing an explanation for the efficacy of these peptides. Identification of more potent and more permeant Smac mimetics will likely be required to translate these findings into strategies that can be tested in the clinic.
Original language | English (US) |
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Pages (from-to) | 1118-1120 |
Number of pages | 3 |
Journal | Cell Death and Differentiation |
Volume | 10 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2003 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology