The role of ubiquitous airborne fungi in chronic rhinosinusitis

Jens U. Ponikau, David A. Sherris, Gail M. Kephart, Cheryl Adolphson, Hirohito Kita

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Chronic rhinosinusitis (CRS) is a confusing disease for both allergists and otorhinolaryngologists, partially due to its poorly understood pathophysiology and partially due to its limited treatment options. Several recent reports now provide evidence for a better understanding of the etiology and the relationship of CRS to airborne fungi, especially to Altemoria. First, the development of novel methods enables detection of certain fungi in mucus from the nasal and paranasal sinus cavities. Second, a non-immunoglobulin E-mediated immunologic mechanism for reactivity of CRS patients to certain common fungi has been described. Third, these fungi are surrounded by eosinophils in vivo, suggesting that they are targeted by eosinophils. Fourth, the preliminary results of studies using antifungal agents to treat patients with CRS are promising. Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalCurrent Allergy and Asthma Reports
Volume5
Issue number6
DOIs
StatePublished - Nov 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

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