TY - JOUR
T1 - The role of ubiquitous airborne fungi in chronic rhinosinusitis
AU - Ponikau, Jens U.
AU - Sherris, David A.
AU - Kephart, Gail M.
AU - Adolphson, Cheryl
AU - Kita, Hirohito
N1 - Funding Information:
Supported by NIH grants AI 50494 and AI 49235 and the Mayo Foundation.
PY - 2005/11
Y1 - 2005/11
N2 - Chronic rhinosinusitis (CRS) is a confusing disease for both allergists and otorhinolaryngologists, partially due to its poorly understood pathophysiology and partially due to its limited treatment options. Several recent reports now provide evidence for a better understanding of the etiology and the relationship of CRS to airborne fungi, especially to Altemoria. First, the development of novel methods enables detection of certain fungi in mucus from the nasal and paranasal sinus cavities. Second, a non-immunoglobulin E-mediated immunologic mechanism for reactivity of CRS patients to certain common fungi has been described. Third, these fungi are surrounded by eosinophils in vivo, suggesting that they are targeted by eosinophils. Fourth, the preliminary results of studies using antifungal agents to treat patients with CRS are promising. Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents.
AB - Chronic rhinosinusitis (CRS) is a confusing disease for both allergists and otorhinolaryngologists, partially due to its poorly understood pathophysiology and partially due to its limited treatment options. Several recent reports now provide evidence for a better understanding of the etiology and the relationship of CRS to airborne fungi, especially to Altemoria. First, the development of novel methods enables detection of certain fungi in mucus from the nasal and paranasal sinus cavities. Second, a non-immunoglobulin E-mediated immunologic mechanism for reactivity of CRS patients to certain common fungi has been described. Third, these fungi are surrounded by eosinophils in vivo, suggesting that they are targeted by eosinophils. Fourth, the preliminary results of studies using antifungal agents to treat patients with CRS are promising. Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents.
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U2 - 10.1007/s11882-005-0028-6
DO - 10.1007/s11882-005-0028-6
M3 - Review article
C2 - 16216172
AN - SCOPUS:28044441661
SN - 1529-7322
VL - 5
SP - 472
EP - 476
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 6
ER -