The role of ubiquitous airborne fungi in chronic rhinosinusitis

Jens U. Ponikau, David A. Sherris, Gail M. Kephart, Cheryl Adolphson, Hirohito Kita

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Chronic rhinosinusitis (CRS) is a confusing disease for both allergists and otorhinolaryngologists, partially due to its poorly understood pathophysiology and partially due to its limited treatment options. Several recent reports now provide evidence for a better understanding of the etiology and the relationship of CRS to airborne fungi, especially to Altemoria. First, the development of novel methods enables detection of certain fungi in mucus from the nasal and paranasal sinus cavities. Second, a non-immunoglobulin E-mediated immunologic mechanism for reactivity of CRS patients to certain common fungi has been described. Third, these fungi are surrounded by eosinophils in vivo, suggesting that they are targeted by eosinophils. Fourth, the preliminary results of studies using antifungal agents to treat patients with CRS are promising. Overall, these recent discoveries provide a logical mechanism for the pathophysiology of CRS, and they also suggest promising avenues for treatment of CRS with antifungal agents.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalCurrent Allergy and Asthma Reports
Volume5
Issue number6
StatePublished - Nov 2005
Externally publishedYes

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Fungi
Antifungal Agents
Paranasal Sinuses
Eosinophils
Mucus
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ponikau, J. U., Sherris, D. A., Kephart, G. M., Adolphson, C., & Kita, H. (2005). The role of ubiquitous airborne fungi in chronic rhinosinusitis. Current Allergy and Asthma Reports, 5(6), 472-476.

The role of ubiquitous airborne fungi in chronic rhinosinusitis. / Ponikau, Jens U.; Sherris, David A.; Kephart, Gail M.; Adolphson, Cheryl; Kita, Hirohito.

In: Current Allergy and Asthma Reports, Vol. 5, No. 6, 11.2005, p. 472-476.

Research output: Contribution to journalArticle

Ponikau, JU, Sherris, DA, Kephart, GM, Adolphson, C & Kita, H 2005, 'The role of ubiquitous airborne fungi in chronic rhinosinusitis', Current Allergy and Asthma Reports, vol. 5, no. 6, pp. 472-476.
Ponikau JU, Sherris DA, Kephart GM, Adolphson C, Kita H. The role of ubiquitous airborne fungi in chronic rhinosinusitis. Current Allergy and Asthma Reports. 2005 Nov;5(6):472-476.
Ponikau, Jens U. ; Sherris, David A. ; Kephart, Gail M. ; Adolphson, Cheryl ; Kita, Hirohito. / The role of ubiquitous airborne fungi in chronic rhinosinusitis. In: Current Allergy and Asthma Reports. 2005 ; Vol. 5, No. 6. pp. 472-476.
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