Abstract
With a set of mc anti-H-2 antibodies to major, spatially separate polymorphic domains, A and B could be identified on the H-2K(k) molecule. Target inhibition by mcAb demonstrates that these two domains harbor also the target sites for alloreactive CTL, and also the restriction sites for H-2 restricted CTL. The majority of both alloreactive and H-2 restricted CTL obtained in mass cultures appeared to be reactive against cluster B determinants. However, in limiting dilution systems several distinct subpopulations were found which differed in their receptor repertoire. Thus, the low frequency populations were predominantly specific for cluster B while the high frequent population contained mainly CTL clones which recognize cluster A. The appearance of these cluster-specific subpopulations seems to be regulated by yet unknown suppressive mechanisms.
Original language | English (US) |
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Pages (from-to) | 90-95 |
Number of pages | 6 |
Journal | Behring Institute Mitteilungen |
Volume | No. 70 |
State | Published - 1982 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)