The role of Treg cells in the cancer immunological response

Zhi Zhang Yang, Stephen M. Ansell

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Problem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, emerging evidence suggests that Treg cells play a pivotal role in tumor immunity and contribute to tumor growth and progression, thereby having an important impact on the outcome of cancer patients. Approach: This article reviewed the medical literature to describe how Treg cells affect anti-tumor immunity. Results: Treg cells suppressed anti-tumor immunity by inhibiting the effector functions of tumor-specific T cells and NK cells. Importantly, tumor cells played an active role in recruiting and generating Treg cells and creating a suppressive tumor microenvironment. Strategies to deplete Treg cells or inhibit their function had yielded promising results by enhancing anti-tumor immunity in experimental studies as well as clinical practice. Conclusion: A better understanding of the pathophysiology of Treg cells not only increased our knowledge in a variety of aspects of immunology but also potentially benefited cancer patients.

Original languageEnglish (US)
Pages (from-to)17-28
Number of pages12
JournalAmerican Journal of Immunology
Volume5
Issue number1
DOIs
StatePublished - Sep 18 2009

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Keywords

  • CD4CD25
  • Cancer
  • Foxp3
  • Immune response
  • T cells
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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