The role of Treg cells in the cancer immunological response

Zhi Zhang Yang, Stephen Maxted Ansell

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Problem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, emerging evidence suggests that Treg cells play a pivotal role in tumor immunity and contribute to tumor growth and progression, thereby having an important impact on the outcome of cancer patients. Approach: This article reviewed the medical literature to describe how Treg cells affect anti-tumor immunity. Results: Treg cells suppressed anti-tumor immunity by inhibiting the effector functions of tumor-specific T cells and NK cells. Importantly, tumor cells played an active role in recruiting and generating Treg cells and creating a suppressive tumor microenvironment. Strategies to deplete Treg cells or inhibit their function had yielded promising results by enhancing anti-tumor immunity in experimental studies as well as clinical practice. Conclusion: A better understanding of the pathophysiology of Treg cells not only increased our knowledge in a variety of aspects of immunology but also potentially benefited cancer patients.

Original languageEnglish (US)
Pages (from-to)17-28
Number of pages12
JournalAmerican Journal of Immunology
Volume5
Issue number1
DOIs
StatePublished - 2009

Fingerprint

Regulatory T-Lymphocytes
Neoplasms
Immunity
Allergy and Immunology
T-Lymphocytes
Immunosuppression
Tumor Microenvironment
Natural Killer Cells
Autoimmune Diseases
Growth

Keywords

  • Cancer
  • CD4CD25
  • Foxp3
  • Immune response
  • T cells
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The role of Treg cells in the cancer immunological response. / Yang, Zhi Zhang; Ansell, Stephen Maxted.

In: American Journal of Immunology, Vol. 5, No. 1, 2009, p. 17-28.

Research output: Contribution to journalArticle

@article{3adcf6280c8c47619a5ac3e3d83dc1e7,
title = "The role of Treg cells in the cancer immunological response",
abstract = "Problem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, emerging evidence suggests that Treg cells play a pivotal role in tumor immunity and contribute to tumor growth and progression, thereby having an important impact on the outcome of cancer patients. Approach: This article reviewed the medical literature to describe how Treg cells affect anti-tumor immunity. Results: Treg cells suppressed anti-tumor immunity by inhibiting the effector functions of tumor-specific T cells and NK cells. Importantly, tumor cells played an active role in recruiting and generating Treg cells and creating a suppressive tumor microenvironment. Strategies to deplete Treg cells or inhibit their function had yielded promising results by enhancing anti-tumor immunity in experimental studies as well as clinical practice. Conclusion: A better understanding of the pathophysiology of Treg cells not only increased our knowledge in a variety of aspects of immunology but also potentially benefited cancer patients.",
keywords = "Cancer, CD4CD25, Foxp3, Immune response, T cells, Tumor immunity",
author = "Yang, {Zhi Zhang} and Ansell, {Stephen Maxted}",
year = "2009",
doi = "10.3844/ajisp.2009.17.28",
language = "English (US)",
volume = "5",
pages = "17--28",
journal = "American Journal of Immunology",
issn = "1553-619X",
publisher = "Science Publications",
number = "1",

}

TY - JOUR

T1 - The role of Treg cells in the cancer immunological response

AU - Yang, Zhi Zhang

AU - Ansell, Stephen Maxted

PY - 2009

Y1 - 2009

N2 - Problem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, emerging evidence suggests that Treg cells play a pivotal role in tumor immunity and contribute to tumor growth and progression, thereby having an important impact on the outcome of cancer patients. Approach: This article reviewed the medical literature to describe how Treg cells affect anti-tumor immunity. Results: Treg cells suppressed anti-tumor immunity by inhibiting the effector functions of tumor-specific T cells and NK cells. Importantly, tumor cells played an active role in recruiting and generating Treg cells and creating a suppressive tumor microenvironment. Strategies to deplete Treg cells or inhibit their function had yielded promising results by enhancing anti-tumor immunity in experimental studies as well as clinical practice. Conclusion: A better understanding of the pathophysiology of Treg cells not only increased our knowledge in a variety of aspects of immunology but also potentially benefited cancer patients.

AB - Problem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, emerging evidence suggests that Treg cells play a pivotal role in tumor immunity and contribute to tumor growth and progression, thereby having an important impact on the outcome of cancer patients. Approach: This article reviewed the medical literature to describe how Treg cells affect anti-tumor immunity. Results: Treg cells suppressed anti-tumor immunity by inhibiting the effector functions of tumor-specific T cells and NK cells. Importantly, tumor cells played an active role in recruiting and generating Treg cells and creating a suppressive tumor microenvironment. Strategies to deplete Treg cells or inhibit their function had yielded promising results by enhancing anti-tumor immunity in experimental studies as well as clinical practice. Conclusion: A better understanding of the pathophysiology of Treg cells not only increased our knowledge in a variety of aspects of immunology but also potentially benefited cancer patients.

KW - Cancer

KW - CD4CD25

KW - Foxp3

KW - Immune response

KW - T cells

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=70249097382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249097382&partnerID=8YFLogxK

U2 - 10.3844/ajisp.2009.17.28

DO - 10.3844/ajisp.2009.17.28

M3 - Article

VL - 5

SP - 17

EP - 28

JO - American Journal of Immunology

JF - American Journal of Immunology

SN - 1553-619X

IS - 1

ER -