The Role of the Pericardium in Heart Failure: Implications for Pathophysiology and Treatment

Barry A Borlaug, Yogesh N.V. Reddy

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical interventions or directly through a number of existing and future therapies.

Original languageEnglish (US)
Pages (from-to)574-585
Number of pages12
JournalJACC: Heart Failure
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Pericardium
Heart Failure
Cardiac Volume
Ventricular Function
Myocardium
Hemodynamics
Health
Therapeutics

Keywords

  • heart failure
  • hemodynamics
  • pericardium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The Role of the Pericardium in Heart Failure : Implications for Pathophysiology and Treatment. / Borlaug, Barry A; Reddy, Yogesh N.V.

In: JACC: Heart Failure, Vol. 7, No. 7, 01.07.2019, p. 574-585.

Research output: Contribution to journalReview article

@article{bfb1b5dd46874d0cbe8b1ef3e5e4993d,
title = "The Role of the Pericardium in Heart Failure: Implications for Pathophysiology and Treatment",
abstract = "The elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical interventions or directly through a number of existing and future therapies.",
keywords = "heart failure, hemodynamics, pericardium",
author = "Borlaug, {Barry A} and Reddy, {Yogesh N.V.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1016/j.jchf.2019.03.021",
language = "English (US)",
volume = "7",
pages = "574--585",
journal = "JACC: Heart Failure",
issn = "2213-1779",
publisher = "Elsevier BV",
number = "7",

}

TY - JOUR

T1 - The Role of the Pericardium in Heart Failure

T2 - Implications for Pathophysiology and Treatment

AU - Borlaug, Barry A

AU - Reddy, Yogesh N.V.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - The elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical interventions or directly through a number of existing and future therapies.

AB - The elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical interventions or directly through a number of existing and future therapies.

KW - heart failure

KW - hemodynamics

KW - pericardium

UR - http://www.scopus.com/inward/record.url?scp=85067347037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067347037&partnerID=8YFLogxK

U2 - 10.1016/j.jchf.2019.03.021

DO - 10.1016/j.jchf.2019.03.021

M3 - Review article

C2 - 31248569

AN - SCOPUS:85067347037

VL - 7

SP - 574

EP - 585

JO - JACC: Heart Failure

JF - JACC: Heart Failure

SN - 2213-1779

IS - 7

ER -