The Role of the Pericardium in Heart Failure: Implications for Pathophysiology and Treatment

Barry A. Borlaug, Yogesh N.V. Reddy

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical interventions or directly through a number of existing and future therapies.

Original languageEnglish (US)
Pages (from-to)574-585
Number of pages12
JournalJACC: Heart Failure
Volume7
Issue number7
DOIs
StatePublished - Jul 2019

Keywords

  • heart failure
  • hemodynamics
  • pericardium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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