The role of Tbx2 and Tbx3 in mammary development and tumorigenesis

Matthew Rowley, Erin Grothey, Fergus J. Couch

Research output: Contribution to journalReview article

76 Scopus citations

Abstract

TBX2 and TBX3 are members of a family of genes encoding developmental transcription factors, characterized by a 200 amino acid DNA binding domain (T-box). Tbx2 and Tbx3 are closely related T-box proteins that have been implicated in development of a number of different tissues including the mammary gland. TBX3 is required for normal mammary development in mouse models and in patients with ulnar-mammary syndrome (UMS). In addition to a role in development, TBX2 and TBX3 have been implicated in tumor development through downregulation of the alternative reading frame (ARF) tumor suppressor and an associated bypass of senescence. Here we review the current information on the roles of Tbx2 and Tbx3 in mammary gland development and tumorigenesis. copy; 2004 Plenum Publishing Corporation.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalJournal of Mammary Gland Biology and Neoplasia
Volume9
Issue number2
DOIs
StatePublished - Apr 1 2004

Keywords

  • Development
  • Mammary
  • Senescence
  • TBX2
  • TBX3

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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