The role of stereotactic radiosurgery in the treatment of malignant skull base tumors

Robert C. Miller, Robert L. Foote, Robert J. Coffey, Deborah A. Gorman, John D. Earle, Paula J. Schomberg, Robert W. Kline

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Purpose: To determine the efficacy and toxicity of stereotactic radiosurgery in the treatment of malignant skull base tumors. Methods and Materials: Thirty-two patients with 35 newly diagnosed or recurrent malignant skull base tumors ≤33.5 cm3 were treated using the Leksell Gamma unit. Tumor histologies included: adenoid cystic carcinoma [12], basal cell carcinoma [1], chondrosarcoma [1], chordoma [8], nasopharyngeal carcinoma [3], osteogenic sarcoma [2], and squamous cell carcinoma [8]. Results: After a median follow-up of 2.3 years, 83% ± 15% (±95% confidence interval) of patients experienced a symptomatic response to treatment. Local control at the skull base was 95 ± 9% at 2 years and 78 ± 23% at 3 years. Local- regional control above the clavicles was 75 ± 15% at 1 year and 51 ± 20% at 2 years. Overall and cause specific survival were identical, 82 ± 13% at 1 year, 76 ± 14% at 2 years, and 72 ± 16% at 3 years. One patient developed a radiation-induced optic neuropathy 12 months after radiosurgery. Conclusion: Stereotactic radiosurgery using the Leksell Gamma Unit can provide durable tumor control and symptomatic relief with acceptable toxicity in the majority of patients with malignant tumors 4 cm or less in size involving the skull base. Further evaluation of more patients with longer follow-up is warranted.

Original languageEnglish (US)
Pages (from-to)977-981
Number of pages5
JournalInternational Journal of Radiation Oncology Biology Physics
Volume39
Issue number5
DOIs
StatePublished - Dec 1 1997

Keywords

  • Base of skull
  • Gamma knife
  • Head and neck cancer
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Miller, R. C., Foote, R. L., Coffey, R. J., Gorman, D. A., Earle, J. D., Schomberg, P. J., & Kline, R. W. (1997). The role of stereotactic radiosurgery in the treatment of malignant skull base tumors. International Journal of Radiation Oncology Biology Physics, 39(5), 977-981. https://doi.org/10.1016/S0360-3016(97)00377-5