The Role of Stem Cell Genomic Instability in Aging

Cynthia J. Hommerding; Bennett G. Childs; Darren J. Baker

doi:10.1007/s40778-015-0020-6

The Role of Stem Cell Genomic Instability in Aging

Cynthia J. Hommerding, Bennett G. Childs, Darren J. Baker

Pediatric and Adolescent Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Organismal aging is characterized by a progressive loss of tissue homeostasis and impaired function over time. Multi-cellular organisms activate stem and progenitor cells to replace damaged cells in order to continuously meet the functional demands of tissues. Along with tissue dysfunction, stem cell self-renewal and differentiation capacities diminish with age in concert with the accumulation of genomic damage, suggesting a potential link between genetic instability and aging. Here, we focus on the types of DNA damage found in aged stem cells, and discuss emerging mechanisms by which genomic instability may contribute to stem cell impairments and organismal aging, with particular emphasis on insights obtained from progeroid mouse models. Additionally, we discuss how age-related systemic changes may impact stem cell genomic integrity and function.

Original language	English (US)
Pages (from-to)	151-161
Number of pages	11
Journal	Current Stem Cell Reports
Volume	1
Issue number	3
DOIs	https://doi.org/10.1007/s40778-015-0020-6
State	Published - Sep 1 2015

Keywords

Aging
DNA damage
Genomic instability
Progeroid
Stem cells

ASJC Scopus subject areas

Molecular Biology
Genetics
Developmental Biology
Cell Biology

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10.1007/s40778-015-0020-6

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title = "The Role of Stem Cell Genomic Instability in Aging",

abstract = "Organismal aging is characterized by a progressive loss of tissue homeostasis and impaired function over time. Multi-cellular organisms activate stem and progenitor cells to replace damaged cells in order to continuously meet the functional demands of tissues. Along with tissue dysfunction, stem cell self-renewal and differentiation capacities diminish with age in concert with the accumulation of genomic damage, suggesting a potential link between genetic instability and aging. Here, we focus on the types of DNA damage found in aged stem cells, and discuss emerging mechanisms by which genomic instability may contribute to stem cell impairments and organismal aging, with particular emphasis on insights obtained from progeroid mouse models. Additionally, we discuss how age-related systemic changes may impact stem cell genomic integrity and function.",

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AU - Hommerding, Cynthia J.

AU - Childs, Bennett G.

AU - Baker, Darren J.

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N2 - Organismal aging is characterized by a progressive loss of tissue homeostasis and impaired function over time. Multi-cellular organisms activate stem and progenitor cells to replace damaged cells in order to continuously meet the functional demands of tissues. Along with tissue dysfunction, stem cell self-renewal and differentiation capacities diminish with age in concert with the accumulation of genomic damage, suggesting a potential link between genetic instability and aging. Here, we focus on the types of DNA damage found in aged stem cells, and discuss emerging mechanisms by which genomic instability may contribute to stem cell impairments and organismal aging, with particular emphasis on insights obtained from progeroid mouse models. Additionally, we discuss how age-related systemic changes may impact stem cell genomic integrity and function.

AB - Organismal aging is characterized by a progressive loss of tissue homeostasis and impaired function over time. Multi-cellular organisms activate stem and progenitor cells to replace damaged cells in order to continuously meet the functional demands of tissues. Along with tissue dysfunction, stem cell self-renewal and differentiation capacities diminish with age in concert with the accumulation of genomic damage, suggesting a potential link between genetic instability and aging. Here, we focus on the types of DNA damage found in aged stem cells, and discuss emerging mechanisms by which genomic instability may contribute to stem cell impairments and organismal aging, with particular emphasis on insights obtained from progeroid mouse models. Additionally, we discuss how age-related systemic changes may impact stem cell genomic integrity and function.

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The Role of Stem Cell Genomic Instability in Aging

Abstract

Keywords

ASJC Scopus subject areas

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