The role of sodium bisulfite in the 1996-1997 USA influenza vaccine recall

Gregory A. Poland

doi:10.1016/S0264-410X(98)00184-4

The role of sodium bisulfite in the 1996-1997 USA influenza vaccine recall

Gregory A. Poland

General Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

During the 1996-1997 influenza season, all the lots of influenza vaccine manufactured by Parke-Davis were recalled. This voluntary recall by the manufacturer was prompted by the finding of decreasing potency of the A/Nanchang/933/95 (H3N2) component of the vaccine. The primary cause of this lowered potency has been identified as primarily due to the presence of sodium bisulfite which was used to neutralize residual formaldehyde which in tutor is used to inactivate the live influenza vaccine strains. This paper reviews these events and what we have learned.

Original language	English (US)
Pages (from-to)	1865-1868
Number of pages	4
Journal	Vaccine
Volume	16
Issue number	19
DOIs	https://doi.org/10.1016/S0264-410X(98)00184-4
State	Published - Nov 1998

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(98)00184-4

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abstract = "During the 1996-1997 influenza season, all the lots of influenza vaccine manufactured by Parke-Davis were recalled. This voluntary recall by the manufacturer was prompted by the finding of decreasing potency of the A/Nanchang/933/95 (H3N2) component of the vaccine. The primary cause of this lowered potency has been identified as primarily due to the presence of sodium bisulfite which was used to neutralize residual formaldehyde which in tutor is used to inactivate the live influenza vaccine strains. This paper reviews these events and what we have learned.",

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AB - During the 1996-1997 influenza season, all the lots of influenza vaccine manufactured by Parke-Davis were recalled. This voluntary recall by the manufacturer was prompted by the finding of decreasing potency of the A/Nanchang/933/95 (H3N2) component of the vaccine. The primary cause of this lowered potency has been identified as primarily due to the presence of sodium bisulfite which was used to neutralize residual formaldehyde which in tutor is used to inactivate the live influenza vaccine strains. This paper reviews these events and what we have learned.

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The role of sodium bisulfite in the 1996-1997 USA influenza vaccine recall

Abstract

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