The role of sodium bisulfite in the 1996-1997 USA influenza vaccine recall

Gregory A. Poland

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

During the 1996-1997 influenza season, all the lots of influenza vaccine manufactured by Parke-Davis were recalled. This voluntary recall by the manufacturer was prompted by the finding of decreasing potency of the A/Nanchang/933/95 (H3N2) component of the vaccine. The primary cause of this lowered potency has been identified as primarily due to the presence of sodium bisulfite which was used to neutralize residual formaldehyde which in tutor is used to inactivate the live influenza vaccine strains. This paper reviews these events and what we have learned.

Original languageEnglish (US)
Pages (from-to)1865-1868
Number of pages4
JournalVaccine
Volume16
Issue number19
DOIs
StatePublished - Nov 1 1998

    Fingerprint

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this