The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life: An analysis by the MPN QOL International Study Group

Holly L. Geyer, Bjorn Andreasson, Heidi E. Kosiorek, Amylou Dueck, Robyn M. Scherber, Kari A. Martin, Kristina A. Butler, Claire N. Harrison, Deepti H. Radia, Francisco Cervantes, Jean Jacques Kiladjian, Andreas Reiter, Gunnar Birgegard, Francesco Passamonti, Zhenya Senyak, Alessandro M. Vannucchi, Chiara Paoli, Zhijian Xiao, Jan Samuelsson, Ruben A. Mesa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODS: A total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTS: Overall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. Conclusions: The results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management.

Original languageEnglish (US)
JournalCancer
DOIs
StateAccepted/In press - 2016

Fingerprint

Sexuality
Quality of Life
Neoplasms
Essential Thrombocythemia
Polycythemia Vera
Primary Myelofibrosis
Population
Symptom Assessment
Immunologic Factors
Therapeutics
Steroids
Organizations
Research

Keywords

  • Hematological neoplasms
  • Myeloproliferative neoplasms
  • Quality of life
  • Sexuality
  • Symptoms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life : An analysis by the MPN QOL International Study Group. / Geyer, Holly L.; Andreasson, Bjorn; Kosiorek, Heidi E.; Dueck, Amylou; Scherber, Robyn M.; Martin, Kari A.; Butler, Kristina A.; Harrison, Claire N.; Radia, Deepti H.; Cervantes, Francisco; Kiladjian, Jean Jacques; Reiter, Andreas; Birgegard, Gunnar; Passamonti, Francesco; Senyak, Zhenya; Vannucchi, Alessandro M.; Paoli, Chiara; Xiao, Zhijian; Samuelsson, Jan; Mesa, Ruben A.

In: Cancer, 2016.

Research output: Contribution to journalArticle

Geyer, HL, Andreasson, B, Kosiorek, HE, Dueck, A, Scherber, RM, Martin, KA, Butler, KA, Harrison, CN, Radia, DH, Cervantes, F, Kiladjian, JJ, Reiter, A, Birgegard, G, Passamonti, F, Senyak, Z, Vannucchi, AM, Paoli, C, Xiao, Z, Samuelsson, J & Mesa, RA 2016, 'The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life: An analysis by the MPN QOL International Study Group', Cancer. https://doi.org/10.1002/cncr.30013
Geyer, Holly L. ; Andreasson, Bjorn ; Kosiorek, Heidi E. ; Dueck, Amylou ; Scherber, Robyn M. ; Martin, Kari A. ; Butler, Kristina A. ; Harrison, Claire N. ; Radia, Deepti H. ; Cervantes, Francisco ; Kiladjian, Jean Jacques ; Reiter, Andreas ; Birgegard, Gunnar ; Passamonti, Francesco ; Senyak, Zhenya ; Vannucchi, Alessandro M. ; Paoli, Chiara ; Xiao, Zhijian ; Samuelsson, Jan ; Mesa, Ruben A. / The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life : An analysis by the MPN QOL International Study Group. In: Cancer. 2016.
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title = "The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life: An analysis by the MPN QOL International Study Group",
abstract = "BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODS: A total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTS: Overall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. Conclusions: The results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management.",
keywords = "Hematological neoplasms, Myeloproliferative neoplasms, Quality of life, Sexuality, Symptoms",
author = "Geyer, {Holly L.} and Bjorn Andreasson and Kosiorek, {Heidi E.} and Amylou Dueck and Scherber, {Robyn M.} and Martin, {Kari A.} and Butler, {Kristina A.} and Harrison, {Claire N.} and Radia, {Deepti H.} and Francisco Cervantes and Kiladjian, {Jean Jacques} and Andreas Reiter and Gunnar Birgegard and Francesco Passamonti and Zhenya Senyak and Vannucchi, {Alessandro M.} and Chiara Paoli and Zhijian Xiao and Jan Samuelsson and Mesa, {Ruben A.}",
year = "2016",
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TY - JOUR

T1 - The role of sexuality symptoms in myeloproliferative neoplasm symptom burden and quality of life

T2 - An analysis by the MPN QOL International Study Group

AU - Geyer, Holly L.

AU - Andreasson, Bjorn

AU - Kosiorek, Heidi E.

AU - Dueck, Amylou

AU - Scherber, Robyn M.

AU - Martin, Kari A.

AU - Butler, Kristina A.

AU - Harrison, Claire N.

AU - Radia, Deepti H.

AU - Cervantes, Francisco

AU - Kiladjian, Jean Jacques

AU - Reiter, Andreas

AU - Birgegard, Gunnar

AU - Passamonti, Francesco

AU - Senyak, Zhenya

AU - Vannucchi, Alessandro M.

AU - Paoli, Chiara

AU - Xiao, Zhijian

AU - Samuelsson, Jan

AU - Mesa, Ruben A.

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODS: A total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTS: Overall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. Conclusions: The results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management.

AB - BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and myelofibrosis, are faced with oppressive symptom profiles that compromise daily functioning and quality of life. Among these symptoms, sexuality-related symptoms have emerged as particularly prominent and largely unaddressed. In the current study, the authors evaluated how sexuality symptoms from MPN relate to other patient characteristics, disease features, treatments, and symptoms. METHODS: A total of 1971 patients with MPN (827 with essential thrombocythemia, 682 with polycythemia vera, 456 with myelofibrosis, and 6 classified as other) were prospectively evaluated and patient responses to the Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC-QLQ C30) were collected, along with information regarding individual disease characteristics and laboratory data. Sexuality scores were compared with an age-matched, healthy control population. RESULTS: Overall, patients with MPN were found to have greater sexual dysfunction compared with the healthy population (MPN-SAF score of 3.6 vs 2.0; P65 years and in those with cytopenias and transfusion requirements, and those receiving certain therapies such as immunomodulators or steroids. Conclusions: The results of the current study identify the topic of sexuality as a prominent issue for the MPN population, and this area would appear to benefit from additional investigation and management.

KW - Hematological neoplasms

KW - Myeloproliferative neoplasms

KW - Quality of life

KW - Sexuality

KW - Symptoms

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U2 - 10.1002/cncr.30013

DO - 10.1002/cncr.30013

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JO - Cancer

JF - Cancer

SN - 0008-543X

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