The role of RUNX2 in osteosarcoma oncogenesis

J. A. Squire, J. W. Martin, M. Zielenska, G. S. Stein, Andre J van Wijnen

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for the RUNX2 platform protein in osteosarcoma oncogenesis. RUNX proteins are DNA-binding transcription factors that regulate the expression of multiple genes involved in cellular differentiation and cell-cycle progression. RUNX2 is genetically essential for developing bone and osteoblast maturation. Studies of osteosarcoma tumours have revealed that the RUNX2 DNA copy number together with RNA and protein levels are highly elevated in osteosarcoma tumors. The protein is also important for metastatic bone disease of prostate and breast cancers, while RUNX2 may have both tumor suppressive and oncogenic roles in bone morphogenesis. This paper provides a synopsis of the current understanding of the functions of RUNX2 and its potential role in osteosarcoma and suggests directions for future study.

Original languageEnglish (US)
Article number282745
JournalSarcoma
Volume2011
DOIs
StatePublished - 2011
Externally publishedYes

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Osteosarcoma
Carcinogenesis
Bone and Bones
Bone Neoplasms
Proteins
Bone Diseases
DNA-Binding Proteins
Osteoblasts
Morphogenesis
Prostatic Neoplasms
Cell Cycle
Transcription Factors
RNA
Breast Neoplasms
Gene Expression
DNA
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Squire, J. A., Martin, J. W., Zielenska, M., Stein, G. S., & van Wijnen, A. J. (2011). The role of RUNX2 in osteosarcoma oncogenesis. Sarcoma, 2011, [282745]. https://doi.org/10.1155/2011/282745

The role of RUNX2 in osteosarcoma oncogenesis. / Squire, J. A.; Martin, J. W.; Zielenska, M.; Stein, G. S.; van Wijnen, Andre J.

In: Sarcoma, Vol. 2011, 282745, 2011.

Research output: Contribution to journalArticle

Squire, JA, Martin, JW, Zielenska, M, Stein, GS & van Wijnen, AJ 2011, 'The role of RUNX2 in osteosarcoma oncogenesis', Sarcoma, vol. 2011, 282745. https://doi.org/10.1155/2011/282745
Squire JA, Martin JW, Zielenska M, Stein GS, van Wijnen AJ. The role of RUNX2 in osteosarcoma oncogenesis. Sarcoma. 2011;2011. 282745. https://doi.org/10.1155/2011/282745
Squire, J. A. ; Martin, J. W. ; Zielenska, M. ; Stein, G. S. ; van Wijnen, Andre J. / The role of RUNX2 in osteosarcoma oncogenesis. In: Sarcoma. 2011 ; Vol. 2011.
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