The role of proteases during apoptosis

Research output: Contribution to journalReview articlepeer-review

528 Scopus citations


The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.

Original languageEnglish (US)
Pages (from-to)587-597
Number of pages11
JournalFASEB Journal
Issue number5
StatePublished - Apr 1996


  • calpains
  • granzymes
  • interleukin-1β converting enzyme
  • programmed cell death
  • serine protease inhibitors
  • ubiquitin

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics


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