The role of proteases during apoptosis

Tushar Patel; Gregory J. Gores; Scott H. Kaufmann

doi:10.1096/fasebj.10.5.8621058

The role of proteases during apoptosis

Tushar Patel, Gregory J. Gores, Scott H. Kaufmann

Research output: Contribution to journal › Review article › peer-review

528 Scopus citations

Abstract

The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.

Original language	English (US)
Pages (from-to)	587-597
Number of pages	11
Journal	FASEB Journal
Volume	10
Issue number	5
DOIs	https://doi.org/10.1096/fasebj.10.5.8621058
State	Published - Apr 1996

Keywords

calpains
granzymes
interleukin-1β converting enzyme
programmed cell death
serine protease inhibitors
ubiquitin

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Genetics

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10.1096/fasebj.10.5.8621058

Cite this

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title = "The role of proteases during apoptosis",

abstract = "The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.",

keywords = "calpains, granzymes, interleukin-1β converting enzyme, programmed cell death, serine protease inhibitors, ubiquitin",

author = "Tushar Patel and Gores, {Gregory J.} and Kaufmann, {Scott H.}",

year = "1996",

month = apr,

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TY - JOUR

T1 - The role of proteases during apoptosis

AU - Patel, Tushar

AU - Gores, Gregory J.

AU - Kaufmann, Scott H.

PY - 1996/4

Y1 - 1996/4

N2 - The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.

AB - The importance of proteases during apoptosis is becoming increasingly apparent. Because apoptosis contributes to a diverse variety of disease processes, understanding the roles played by proteases and their inhibitors might provide insight into the pathogenesis of these conditions and suggest novel therapeutic strategies. In this review, we discuss the involvement and role of specific proteases, substrates, and protease inhibitors that appear to participate in the apoptotic process.

KW - calpains

KW - granzymes

KW - interleukin-1β converting enzyme

KW - programmed cell death

KW - serine protease inhibitors

KW - ubiquitin

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U2 - 10.1096/fasebj.10.5.8621058

DO - 10.1096/fasebj.10.5.8621058

M3 - Review article

C2 - 8621058

AN - SCOPUS:0029927422

SN - 0892-6638

VL - 10

SP - 587

EP - 597

JO - FASEB Journal

JF - FASEB Journal

IS - 5

ER -

The role of proteases during apoptosis

Abstract

Keywords

ASJC Scopus subject areas

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